The GATA family (vertebrates and invertebrates)

被引：484
作者：
Patient, RK [1 ]
McGhee, JD
机构：
[1] Univ Nottingham, Queens Med Ctr, Genet Inst, Nottingham NG7 2UH, England
[2] Univ Calgary, Dept Biochem & Mol Biol, Genes & Dev Res Grp, Calgary, AB T2N 4N1, Canada
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 04期
关键词：
D O I：
10.1016/S0959-437X(02)00319-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the past year, vertebrate GATA factors have been found to participate directly in several signal-transduction pathways. Smad3, phosphorylated by TGF-beta signalling, interacts with GATA3 to induce differentiation of T helper cells. Hypertrophic stimuli act through RhoA GTPase and ROCK kinase to activate GATA4 in cardiac myocytes. In the liver, GATA4 is elevated by BMP and FGF signalling, and is able to bind to chromatin targets. Invertebrate GATA factors play a central role in specifying the mesendoderm.
引用
收藏
页码：416 / 422
页数：7
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