Crocetin Alleviates Inflammation in MPTP-Induced Parkinson's Disease Models through Improving Mitochondrial Functions

被引：22

作者：

Dong, Na ^{[1
]}

Dong, Zhong ^{[1
]}

Chen, Ying ^{[2
]}

Gu, Xiaosu ^{[2
]}

机构：

[1] Tianjin Huanhu Hosp, Dept Neurol, Tianjin 300350, Peoples R China

[2] Nantong Univ, Dept Neurol, Affliated Hosp, Nantong 226001, Jiangsu, Peoples R China

来源：

PARKINSONS DISEASE | 2020年 / 2020卷

关键词：

MOUSE MODEL; DYSFUNCTION; CHOLESTEROL; MECHANISMS; RATS;

D O I：

10.1155/2020/9864370

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. However, the effect of crocetin on PD remains unclear. In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the underlying mechanisms. Our results showed that crocetin treatment attenuates MPTP-induced motor deficits and protects dopaminergic neurons. Bothin vivoandin vitroexperiments demonstrated that crocetin treatment decreased the expression of inflammatory associated genes and inflammatory cytokines. Furthermore, crocetin treatment protected mitochondrial functions against MPP+ induced damage by regulating the mPTP (mitochondrial permeability transition pore) viability in the interaction of ANT (adenine nucleotide translocase) and Cyp D (Cyclophilin D) dependent manner. Therefore, our results demonstrate that crocetin has therapeutic potential in Parkinson's disease.

引用

页数：9

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