Liquid biopsies and cancer omics

被引：65

作者：

Amelio, Ivano ^{[1
,2
]}

Bertolo, Riccardo ^{[1
,3
]}

Bove, Pierluigi ^{[1
,3
]}

Buonomo, Oreste Claudio ^{[1
]}

Candi, Eleonora ^{[1
]}

Chiocchi, Marcello ^{[1
]}

Cipriani, Chiara ^{[1
,3
]}

Di Daniele, Nicola ^{[1
]}

Ganini, Carlo ^{[1
]}

Juhl, Hartmut ^{[4
]}

Mauriello, Alessandro ^{[1
]}

Marani, Carla ^{[1
,3
]}

Marshall, John ^{[5
]}

Montanaro, Manuela ^{[1
]}

Palmieri, Giampiero ^{[1
]}

Piacentini, Mauro ^{[1
]}

Sica, Giuseppe ^{[1
]}

Tesauro, Manfredi ^{[1
]}

Rovella, Valentina ^{[1
]}

Tisone, Giuseppe ^{[1
]}

Shi, Yufang ^{[1
,6
,7
,8
]}

Wang, Ying ^{[6
]}

Melino, Gerry ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med, TOR, Torvergata Oncosci Res Ctr Excellence, I-00133 Rome, Italy

[2] Univ Nottingham, Sch Life Sci, Nottingham, England

[3] San Carlo Nancy Hosp, Rome, Italy

[4] Indivumed GmbH, Hamburg, Germany

[5] Georgetown Univ, Medstar Georgetown Univ Hosp, Washington, DC USA

[6] Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China

[7] Soochow Univ, Affiliated Hosp 1, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

[8] Soochow Univ, State Key Lab Radiat Med & Protect, Inst Translat Med, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

CELL DEATH DISCOVERY | 2020年 / 6卷 / 01期

关键词：

HIGH-RISK NEUROBLASTOMA; BREAST-CANCER; MOLECULAR-MECHANISMS; CELLSEARCH PLATFORM; DATA INTEGRATION; TUMOR-CELLS; SURVIVAL; DNA; MUTATIONS; HETEROGENEITY;

D O I：

10.1038/s41420-020-00373-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still relies on tissue biopsies, which are unable to capture the dynamic nature of cancer through its evolution. This assumption led to the exploration of non-tissue sources of tumoral material opening the field of liquid biopsies. Blood, together with body fluids such as urines, or stool, from cancer patients, are analyzed applying the techniques used for the generation of omics data. With blood, this approach would allow to take into account tumor heterogeneity (since the circulating components such as CTCs, ctDNA, or ECVs derive from each cancer clone) in a time dependent manner, resulting in a somehow "real-time" understanding of cancer evolution. Liquid biopsies are beginning nowdays to be applied in many cancer contexts and are at the basis of many clinical trials in oncology.

引用

页数：8

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