Lack of effect of secretin on kindling and seizures

被引:1
作者
Zhao, Qian [1 ]
Boismenu, Richard
Rusche, James R.
Holmes, Gregory L.
机构
[1] Dartmouth Med Sch, Neurosci Ctr Dartmouth, Neurol Sect, Lebanon, NH 03756 USA
[2] Repligen Corp, Waltham, MA USA
关键词
kindling; seizures; hippocampus; epilepsy; secretin; vagus nerve;
D O I
10.1016/j.yebeh.2006.04.006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Secretin infused into rats activates neurons located in brain areas controlling autonomic function and emotion. The brain activity of secretin is mediated, at least in part, through vagal pathways. It is known that afferent stimulation of the vagus nerve results in considerable antiepileptic effects. Whether or not secretin has an effect on seizures is unknown. In this study, we evaluated the efficacy and safety of secretin as an antiepileptogenic agent in electrical kindling and as an anticonvulsant in fully kindled seizures. To assess antiepileptogenic effects, we administered secretin (10, 30, or 100 mu g/kg/dose) or normal saline intravenously 5 min before twice-daily kindling stimulation. To assess the anticonvulsant effect of secretin, we administered either normal saline or secretin (100 mu g/kg/dose) 5 min before the electrical stimulation to fully kindled rats. We observed no effect on kindling rate or afterdischarge duration. In fully kindled rats, secretin administration had no effect on kindling stage or afterdischarge duration. Thus, in the dose range used in this preliminary acute treatment study, secretin had no discernible antiepileptogenic or anticonvulsant effects. Secretin was very well tolerated in this multidose protocol. (C) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:46 / 50
页数:5
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