Cyanidin-3-glucoside ameliorates CCl4-induced liver injury in mice

被引：13

作者：

Cho, Byoung Ok ^{[1
]}

Lee, Chang Wook ^{[1
,3
]}

So, Yangkang ^{[1
]}

Jin, Chang Hyun ^{[1
]}

Kang, Si Yong ^{[1
]}

Kim, Dong Sub ^{[1
]}

Seo, Kwon Il ^{[2
]}

Yook, Hong Sun ^{[3
]}

Jeong, Il Yun ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, Jeonbuk, South Korea

[2] Sunchon Natl Univ, Dept Food & Nutr, Sunchon 540742, Jeonnam, South Korea

[3] Chungnam Natl Univ, Dept Food Sci & Human Nutr, Taejon 305764, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2014年 / 23卷 / 04期

关键词：

carbon tetrachloride; cyanidin-3-glucoside; lipid peroxidation; liver injury; INDUCED OXIDATIVE STRESS; MEDIATED DNA-DAMAGE; NF-KAPPA-B; CARBON-TETRACHLORIDE; PROTECTS; ACTIVATION; CYANIDIN; JUICE; RAT;

D O I：

10.1007/s10068-014-0180-7

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The protective effect of cyanidin-3-glucoside (C3G) against carbon tetrachloride (CCl4)-induced liver injury in mice was investigated. Administration of C3G attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in CCl4-treated mice. Histopathological examination of mouse livers showed that C3G reduced the incidence of liver lesions induced by CCl4. Moreover, C3G prevented DNA damage and decreased the protein levels of gamma-H2AX in CCl4-treated mouse livers. C3G also increased the activity of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, which were decreased due to CCl4 administration in CCl4-treated mouse livers. C3G inhibited the expression levels of IL-6 and iNOS in CCl4-treated mice. C3G apparently protects the liver from CCl4-induced hepatic damage through antioxidant and anti-inflammatory mechanisms.

引用

页码：1313 / 1319

页数：7

共 30 条

[1] Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride [J].

Adesanoye, Omolola A. ;

Farombi, Ebenezer O. .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2010, 62 (02) :197-206

[2] Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: Modulation of NF-κB, cytokine production and oxidative stress [J].

Aldaba-Muruato, Liseth R. ;

Moreno, Mario G. ;

Shibayama, Mineko ;

Tsutsumi, Victor ;

Muriel, Pablo .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (02) :65-75

[3] Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes [J].

Andres Rubiolo, Juan ;

Mithieux, Gilles ;

Victor Vega, Felix .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 591 (1-3) :66-72

[4] Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress [J].

Beddowes, EJ ;

Faux, SP ;

Chipman, JK .

TOXICOLOGY, 2003, 187 (2-3) :101-115

[5] Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo [J].

Chen, Pei-Ni ;

Chu, Shu-Chen ;

Chiou, Hui-Ling ;

Chiang, Chui-Liang ;

Yang, Shun-Fa ;

Hsieh, Yih-Shou .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2005, 53 (02) :232-243

[6] Hepatoprotective effect of 2,3-dehydrosilybin on carbon tetrachloride-induced liver injury in rats [J].

Cho, Byoung-Ok ;

Ryu, Hyung-Won ;

So, Yangkang ;

Jin, Chang-Hyun ;

Baek, Ji-Yeong ;

Park, Ki-Hun ;

Byun, Eui-Hong ;

Jeong, Il-Yun .

FOOD CHEMISTRY, 2013, 138 (01) :107-115

[7]

Choi JM, 2006, FOOD SCI BIOTECHNOL, V15, P728

[8] Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats [J].

Dhanasekaran, Muniyappan ;

Ignacimuthu, Savarimuthu ;

Agastian, Paul .

PHYTOMEDICINE, 2009, 16 (09) :891-895

[9] Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity [J].

Ding, Min ;

Feng, Rentian ;

Wang, Shiow Y. ;

Bowman, Linda ;

Lu, Yongju ;

Qian, Yong ;

Castranova, Vincent ;

Jiang, Bing-Hua ;

Shi, Xianglin .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (25) :17359-17368

[10] Resveratrol ameliorates carbon tetrachloride-induced acute liver injury in mice [J].

Fan, Guijuan ;

Tang, Jiang Jiang ;

Bhadauria, Monika ;

Nirala, Satendra Kumar ;

Dai, Fang ;

Zhou, Bo ;

Li, Yang ;

Liu, Zhong Li .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2009, 28 (03) :350-356

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