The role of stem cell transplantation in the management of relapsed follicular lymphoma in the era of targeted therapies

被引：11
作者：
Norman, Jane E. [1 ]
Schouten, Harry C. [2 ]
Dreger, Peter [3 ]
Robinson, Stephen P. [4 ]
机构：
[1] Manchester Royal Infirm, Dept Haematol, Manchester, Lancs, England
[2] Univ Hosp Maastricht, Dept Internal Med Hematol, Maastricht, Netherlands
[3] Heidelberg Univ, Dept Haematol & Oncol, Heidelberg, Germany
[4] Bristol Oncol & Haematol Ctr, Dept Haematol, Bristol, Avon, England
来源：
BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / 06期
关键词：
NON-HODGKIN-LYMPHOMA; TERM-FOLLOW-UP; BONE-MARROW-TRANSPLANTATION; PROGRESSION-FREE SURVIVAL; HIGH-DOSE THERAPY; CHRONIC LYMPHOCYTIC-LEUKEMIA; CHIMERIC-ANTIGEN-RECEPTOR; LOW-GRADE; OPEN-LABEL; PHASE-II;
D O I：
10.1038/s41409-018-0372-5
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Patients with relapsed follicular lymphoma (FL) following first-line therapy have an increasing number of management strategies ranging from observation through to stem cell transplantation. There has been an exciting expansion in novel agents to treat FL, but at present there is not a universally accepted standard of care in the relapse setting. Decision-making can be difficult for the clinician as there is a paucity of data to compare the various relapse therapies available. This review will discuss conventional therapy for relapsed FL, consider the use of novel agents and explore the role and timing of autologous and allogeneic stem cell transplantation.
引用
收藏
页码：787 / 797
页数：11
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