Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera

被引：49

作者：

Chen, Qi-Bin ^{[1
,2
,3
]}

Xin, Xue-Lei ^{[1
,2
]}

Yang, Yi ^{[1
,2
]}

Lee, Shoei-Sheng ^{[4
]}

Aisa, H. A. ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China

[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

[4] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期

基金：

中国国家自然科学基金;

关键词：

METABOLISM-PROMOTING ACTIVITIES; DITERPENE ALKALOIDS; CIRCULAR-DICHROISM; SATIVA; SEEDS;

D O I：

10.1021/np4009078

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 mu M.

引用

页码：807 / 812

页数：6

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