Immunotoxin therapy of cancer

被引：414
作者：
Pastan, Ira [1 ]
Hassan, Raffit [1 ]
FitzGerald, David J. [1 ]
Kreitman, Robert J. [1 ]
机构：
[1] NCI, Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 07期
关键词：
D O I：
10.1038/nrc1891
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rationally designed anticancer agents that target cell-surface antigens or receptors represent a promising approach for treating cancer patients. However, antibodies that bind these targets are often, by themselves, non-cytotoxic. By attaching potent toxins we can dramatically improve the clinical utility of some anti-tumour antibodies. Here we describe the construction and clinical utility of several recombinant immunotoxins; each of which is composed of antibody Fv fragments fused to powerful bacterial toxins. Results from clinical trials indicate that recombinant immunotoxins and similar agents that are designed to combine antibody selectivity with toxin cell-killing potency will be useful additions to cancer therapy.
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页码：559 / 565
页数：7
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