Fos-icking for control of angiogenesis: increasing the longevity of peritoneal dialysis

被引：5
作者：
Bonder, Claudine S. [1 ,2 ,3 ]
Ebert, Lisa M. [1 ,2 ]
机构：
[1] SA Pathol, Ctr Canc Biol, Adelaide, SA 5000, Australia
[2] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia
[3] Univ Adelaide, Sch Med, Adelaide, SA, Australia
来源：
KIDNEY INTERNATIONAL | 2013年 / 84卷 / 06期
关键词：
D O I：
10.1038/ki.2013.306
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Recurring peritonitis reduces the effectiveness of peritoneal dialysis by increasing fibrosis and angiogenesis, ultimately causing ultrafiltration failure (UFF). Identifying the processes underlying UFF will provide new hope for patients with chronic kidney disease. Catar and colleagues demonstrate that transforming growth factor-beta, tumor necrosis factor-alpha, and interleukin-1 synergize to significantly increase the production and release of vascular endothelial growth factor by mesothelial cells, which, if untreated, will promote peritoneal angiogenesis, leading to UFF.
引用
收藏
页码：1065 / 1067
页数：3
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