Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities

被引：21

作者：

Liu, Wei ^{[1
,2
,3
,4
]}

Gao, Jie ^{[3
]}

Li, Miaomiao ^{[3
]}

Aisa, Haji Akber ^{[1
,2
]}

Yuan, Tao ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China

[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China

[3] Jiangxi Normal Univ, Coll Life Sci, Lab Effect Subst Jiangxi Genuine Med Mat, Nanchang 330022, Jiangxi, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

PHYTOCHEMISTRY | 2021年 / 182卷

基金：

中国国家自然科学基金;

关键词：

Pistacia lentiscus; Anacardiaceae; Tirucallane triterpenoid; Anti-inflammatory; Cytotoxicity; IN-VITRO;

D O I：

10.1016/j.phytochem.2020.112596

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of mastic, a resin produced by Pistacia lentiscus, led to the isolation and identification of 16 tirucallane triterpenoids, 13 (1-13) of which are undescribed. Their structures and absolute configurations were elucidated based on the analysis of spectroscopic data and single-crystal X-ray diffraction. Compounds 12 and 13 are unusual 7(8 -> 9)abeo-tirucallane triterpenoids. Anti-inflammatory assays indicated that compounds 7, 8, 14, and 16 exhibited stronger inhibitory NO production activities (IC50 = 7.7-13.4 mu M) than that of the positive control dexamethasone (IC50 = 19.5 mu M). In addition, compound 1 showed comparable cytotoxic activity against HepG2 cells to that of doxorubicin (IC50 = 4.92 VS 1.34 mu M).

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