Endocytoscopy can be used to assess histological healing in ulcerative colitis

被引：42
作者：
Nakazato, Yoshihiro [1 ,2 ]
Naganuma, Makoto [1 ]
Sugimoto, Shinya [1 ]
Bessho, Rieko [3 ]
Arai, Mari [1 ]
Kiyohara, Hiroki [1 ]
Ono, Keiko [1 ]
Nanki, Kosaku [1 ]
Mutaguchi, Makoto [1 ]
Mizuno, Shinta [1 ]
Kobayashi, Taku [1 ]
Hosoe, Naoki [2 ]
Shimoda, Masayuki [4 ]
Abe, Takayuki [5 ]
Inoue, Nagamu [3 ]
Ogata, Haruhiko [2 ]
Iwao, Yasushi [3 ]
Kanai, Takanori [1 ]
机构：
[1] Keio Univ, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Tokyo, Japan
[2] Keio Univ, Ctr Diagnost & Therapeut Endoscopy, Sch Med, Tokyo, Japan
[3] Keio Univ, Sch Med, Ctr Prevent Med, Tokyo, Japan
[4] Keio Univ, Sch Med, Dept Pathol, Tokyo, Japan
[5] Keio Univ, Sch Med, Dept Prevent Med & Publ Hlth, Tokyo, Japan
来源：
ENDOSCOPY | 2017年 / 49卷 / 06期
关键词：
RELAPSE; PARAMETERS; PREDICTORS; OUTCOMES;
D O I：
10.1055/s-0043-106556
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS. Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent [CS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0.The diagnostic accuracy of the ECS score for histological remission (Geboes score 2) was also assessed. Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a lc value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86. Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.
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页码：560 / 563
页数：4
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