Stereoselective Synthesis of -Amino Ketones: A Three-Component Mannich-Type Reaction of Aromatic Aldehydes, Anilines, and Cyclohexanone Using Amberlyst-15

被引：7

作者：

Das, Biswanath ^{[1
]}

Kumar, Avula Satya ^{[1
]}

Kanth, Bommena Ravi ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 17期

关键词：

Amberlyst-15; -amino ketone; Mannich-type reaction; stereoselective synthesis; three-component reaction; HETEROGENEOUS RECYCLABLE CATALYST; EFFICIENT; ALCOHOLS; SILICA; WATER; ACIDS;

D O I：

10.1080/00397910902730960

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component Mannich-type reaction of aromatic aldehydes, anilines, and cyclohexanone in the presence of Amberlyst-15 affords the corresponding -amino ketones in good yields at room temperature. The conversion is highly diastereoselective, favoring the formation of anti-isomers.

引用

页码：3111 / 3118

页数：8

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