Chitosan membranes modified by contact with poly(acrylic acid)

被引：22

作者：

De Lima, M. S. P. ^{[1
]}

Freire, M. S. ^{[1
]}

Fonseca, J. L. C. ^{[1
]}

Pereira, M. R. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Dept Quim, BR-59078970 Natal, RN, Brazil

来源：

CARBOHYDRATE RESEARCH | 2009年 / 344卷 / 13期

关键词：

Chitosan membrane; Poly(acrylic acid); Permeability; Polyelectrolyte complex; INTERPOLYMER COMPLEXES; RELEASE KINETICS; DRUG-DELIVERY; CROSS-LINKING; IN-VITRO; NETWORK; PERVAPORATION; MICROSPHERES; PERMEABILITY; TRANSPORT;

D O I：

10.1016/j.carres.2009.05.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work chitosan membranes modified by contact with poly(acrylic acid) (PAA) aqueous solution at two different temperatures (25 degrees C and 60 degrees C) were obtained. The pure chitosan (CS) membranes, as well as those treated with PAA (CSPAA_25 and CSPAA_60) were characterized by FTIR-ATR, water sorption capacity, thermal analysis (TG/DTG), and scanning electron microscopy (SEM). In addition, in vitro permeation experiments were carried out using metronidazol and sodium sulfamerazine aqueous solutions at 0.1% and 0.2% as model drugs. FTIR-ATR results showed the presence of absorption bands of NH3+ and COO- indicating the formation of a polyelectrolyte complex between chitosan and poly(acrylic acid). The results also indicated that PAA penetrates deeper into the membrane at higher temperature (60 degrees C), forming a thicker complex layer. Polyelectrolyte complex formation as well as the influence of treatment temperature was confirmed by lower hydrophilicity, higher thermal stability, and lower permeability of the treated membranes. The results show that the methodology used is a simple and very efficient way to drastically change some membrane properties, especially their permeability. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1709 / 1715

页数：7

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