Elevated dopamine D1 receptor availability in striatum of Gottingen minipigs after electroconvulsive therapy

被引:13
作者
Landau, Anne M. [1 ,2 ,3 ,4 ]
Alstrup, Aage K. O. [1 ,2 ]
Audrain, Helene [1 ,2 ]
Jakobsen, Steen [1 ,2 ]
Simonsen, Mette [1 ,2 ]
Moller, Arne [1 ,2 ,4 ]
Videbech, Poul [5 ,6 ]
Wegener, Gregers [3 ]
Gjedde, Albert [1 ,2 ,7 ,8 ,9 ]
Doudet, Doris J. [1 ,2 ,10 ]
机构
[1] Aarhus Univ & Hosp, Dept Nucl Med, Aarhus C, Denmark
[2] Aarhus Univ & Hosp, PET Ctr, Aarhus C, Denmark
[3] Aarhus Univ & Hosp, Translat Neuropsychiat Unit, Aarhus C, Denmark
[4] Aarhus Univ & Hosp, Ctr Funct Integrat Neurosci, Aarhus C, Denmark
[5] Ctr Mental Hlth, Glostrup, Denmark
[6] Univ Copenhagen, Copenhagen, Denmark
[7] Univ Copenhagen, Ctr Neurosci, Copenhagen, Denmark
[8] Univ Southern Denmark, Dept Nucl Med, Odense, Denmark
[9] Odense Univ Hosp, Odense, Denmark
[10] Univ British Columbia, Dept Med Neurol, Vancouver, BC, Canada
基金
英国医学研究理事会;
关键词
Dopamine; 1; receptor; electroconvulsive therapy; minipig; PET; SCH23390; PARKINSONS-DISEASE; NONHUMAN-PRIMATES; RAT-BRAIN; SHOCK; BINDING; ECT; D-1; DEPRESSION; INCREASES; MECHANISM;
D O I
10.1177/0271678X17705260
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Electroconvulsive therapy (ECT), a direct form of brain stimulation, is an effective antidepressant. We hypothesized that the beneficial effects of ECT are mediated by increased dopaminergic neurotransmission, in which the baseline activity of D1 receptors may predict the response to ECT. We established a novel model of brain stimulation in Gottingen minipigs based on the protocol of ECT applied in humans. With positron emission tomography (PET), we determined a measure of dopaminergic neurotransmission with the dopamine D1 receptor antagonist [C-11]SCH23390. Seven minipigs were anesthetized and completed PET at baseline, prior to the onset of ECT treatment, and at 24-48 h and 8-10 days after the end of a clinical course of ECT, consisting of 10 ECT sessions over a 3.5-week period. In all pigs, the binding of [C-11]SCH23390 to striatal D1 receptors had increased by 24-48 h after ECT, and in most, binding returned towards baseline at 8-10 days. Increased binding was observed in inverse proportion to baseline binding rates. Increased binding to dopamine D1 receptors suggests facilitation of dopaminergic neurotransmission, which may contribute to the therapeutic effects of ECT. Importantly, the baseline binding capacity of D1 receptors predicts the magnitude of increased binding, up to a maximum binding capacity.
引用
收藏
页码:881 / 887
页数:7
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