The Role of DNA Methylation in Cancer

被引：145

作者：

Lakshminarasimhan, Ranjani ^{[1
]}

Liang, Gangning ^{[1
]}

机构：

[1] Univ Southern Calif, Dept Urol, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

来源：

DNA METHYLTRANSFERASES - ROLE AND FUNCTION | 2016年 / 945卷

关键词：

TUMOR-SUPPRESSOR GENE; CPG ISLAND HYPERMETHYLATION; PROMOTER METHYLATION; IGF2; GENE; EPIGENETIC EVENTS; BODY METHYLATION; HUMAN GENOME; CELLS; EXPRESSION; HYPOMETHYLATION;

D O I：

10.1007/978-3-319-43624-1_7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The malignant transformation of normal cells is driven by both genetic and epigenetic changes. With the advent of next-generation sequencing and large-scale multinational consortium studies, it has become possible to profile the genomes and epigenomes of thousands of primary tumors from nearly every cancer type. From these genome-wide studies, it became clear that the dynamic regulation of DNA methylation is a critical epigenetic mechanism of cancer initiation, maintenance, and progression. Proper control of DNA methylation is not only crucial for regulating gene transcription, but its broader consequences include maintaining the integrity of the genome and modulating immune response. Here, we describe the aberrant DNA methylation changes that take place in cancer and how they contribute to the disease phenotype. Further, we highlight potential clinical implications of these changes in the context of prognostic and diagnostic biomarkers, as well as therapeutic targets.

引用

页码：151 / 172

页数：22

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