3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds

被引：47

作者：

Hradil, P. ^{[1
]}

Hlavac, J. ^{[1
]}

Soural, M. ^{[1
]}

Hajduch, M. ^{[2
,3
]}

Kolar, M. ^{[4
]}

Vecerova, R. ^{[4
]}

机构：

[1] Palacky Univ, Fac Sci, Dept Organ Chem, Olomouc 77146, Czech Republic

[2] Palacky Univ, Fac Med & Dent, Dept Sof Pediat & Oncol, Expt Med Lab, Olomouc 77520, Czech Republic

[3] Fac Hosp Olomouc, Olomouc 77520, Czech Republic

[4] Palacky Univ, Fac Med & Dent, Dept Microbiol, Olomouc 77515, Czech Republic

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 06期

关键词：

Quinolinones; anticancer activity; antibacterial activity; inhibition; ALKALOIDS; CELLS;

D O I：

10.2174/138955709788452720

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.

引用

页码：696 / 702

页数：7

共 27 条

[1]

Behrman J.E., 1995, J CHEM RES SYNOP, V5, P164

[2] THE ZOOCHROME OF THE SPONGE VERONGIA-AEROPHOBA (URANIDINE) [J].

CIMINO, G ;

DEROSA, S ;

DESTEFANO, S ;

SPINELLA, A ;

SODANO, G .

TETRAHEDRON LETTERS, 1984, 25 (27) :2925-2928

[3] Pharmacological activities of natural triterpenoids and their therapeutic implications [J].

Dzubak, Petr ;

Hajduch, Marian ;

Vydra, David ;

Hustova, Alica ;

Kvasnica, Miroslav ;

Biedermann, David ;

Markova, Lenka ;

Urban, Milan ;

Sarek, Jan .

NATURAL PRODUCT REPORTS, 2006, 23 (03) :394-411

[4]

Gao F., 1996, J CHEM SOC, P269, DOI DOI 10.1039/P29960000269

[5]

Heravi MM, 2006, INDIAN J CHEM B, V45, P779

[6] Preparation of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones and the influence of substitution on the course of cyclization [J].

Hradil, P ;

Hlavác, J ;

Lemr, K .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 36 (01) :141-144

[7] SYNTHESIS OF 2-ARYL-3-HYDROXYQUINOLIN-4(1H)-ONES [J].

HRADIL, P ;

JIRMAN, J .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1995, 60 (08) :1357-1366

[8] Preparation of 2-phenyl-2-hydroxymethyl-4-oxo-1,2,3,4-tetrahydroquinazoline and 2-methyl-4-oxo-3,4-dihydroquinazoline derivatives formation [J].

Hradil, P ;

Kvapil, L ;

Hlavác, J ;

Weidlich, T ;

Lycka, A ;

Lemr, K .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (04) :831-837

[9]

IWANOWICZ EJ, CAS1353444472 BRIST

[10]

KREJCI P, CAS148331570 U PAL

← 1 2 3 →