Isolation and structure of prorocentrolide B, a fast-acting toxin from Prorocentrum maculosum

被引：66
作者：
Hu, TM
deFreitas, ASW
Curtis, JM
Oshima, Y
Walter, JA
Wright, JLC
机构：
[1] NATL RES COUNCIL CANADA, INST MARINE BIOSCI, HALIFAX, NS B3H 3Z1, CANADA
[2] TOHOKU UNIV, FAC AGR, AOBA KU, SENDAI, MIYAGI, JAPAN
来源：
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 11期
关键词：
D O I：
10.1021/np960439y
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new toxin, prorocentrolide B (1), has been isolated following bioassay-guided fractionation of a BuOH extract of the tropical dinoflagellate, Prorocentrum maculosum Faust. This compound produces a rapid toxic response in the mouse bioassay, a type of activity not accounted for by other diarrhetic shellfish poisoning toxins produced by P. maculosum. The structure 1 was established by NMR and MS and is similar to prorocentrolide (2), a toxin from a strain of Prorocentrum lima. NMR data and the modeling program ConGen have been used to establish the relative stereochemistry of some individual ether ring systems and the hexahydroisoquinoline ring.
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页码：1010 / 1014
页数：5
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