Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

被引：62

作者：

Desjardins, David ^{[1
]}

Cacho-Valadez, Briseida ^{[1
]}

Liu, Ju-Ling ^{[1
]}

Wang, Ying ^{[1
]}

Yee, Callista ^{[1
]}

Bernard, Kristine ^{[1
]}

Khaki, Arman ^{[1
]}

Breton, Lionel ^{[2
]}

Hekimi, Siegfried ^{[1
]}

机构：

[1] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[2] LOreal Res & Innovat, F-93600 Aulnay Sous Bois, France

来源：

AGING CELL | 2017年 / 16卷 / 01期

关键词：

aging; antioxidants; C; elegans; prooxidants; reactive oxygen species; LIFE-SPAN; PROOXIDANT ACTIVITY; CALORIC RESTRICTION; OXIDATIVE DAMAGE; RESVERATROL; LONGEVITY; ROS; MITOHORMESIS; RESPIRATION; MECHANISMS;

D O I：

10.1111/acel.12528

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N-acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake, mitochondrial function, and ROS metabolism. We observed that like pro-oxidants, antioxidants can both lengthen and shorten lifespan, dependent on concentration, genotypes, and conditions. The effects of antioxidants thus reveal an inverted U-shaped dose-response relationship between ROS levels and lifespan. In addition, we observed that RSV can act additively to both NAC and paraquat, to dramatically increase lifespan. This suggests that the effect of compounds that modulate ROS levels can be additive when their loci of action or mechanisms of action are sufficiently distinct.

引用

页码：104 / 112

页数：9