共 45 条
Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice
被引:70
作者:

Decressac, Mickael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France

论文数: 引用数:
h-index:
机构:

Veran, Julien
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France

Cantereau, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France

Jaber, Mohamed
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France

Gaillard, Afsaneh
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France
机构:
[1] Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, F-86022 Poitiers, France
关键词:
NPY;
SVZ;
Neuroproliferation;
Migration;
Neuronal differentiation;
HUNTINGTONS-DISEASE BRAIN;
RAT-BRAIN;
PANCREATIC-POLYPEPTIDE;
NEUROTROPHIC FACTOR;
PROGENITOR CELLS;
NERVOUS-SYSTEM;
SOX2;
FUNCTIONS;
PEPTIDE-YY;
STEM-CELLS;
NEURONS;
D O I:
10.1016/j.nbd.2009.02.017
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The neuropeptide Y (NPY) is widely expressed in the central nervous system and has been shown to stimulate neurogenesis in the hippocampus and the olfactory epithelium. Here, we demonstrate that intracerebroventricular injection of NPY stimulates proliferation of neural precursors in the mice subventricular zone (SVZ), one the most neurogenic areas of the brain. Newly generated neuroblasts migrate through the rostral migratory stream to the olfactory bulb and also directly to the striatum, as evidenced by BrdU labelling and cell phenotyping. Using knock-out mice, specific NPY receptor agonists and antagonists, we report that this neuroproliferative effect is mediated by the Y1 receptor subtype that we found to be highly expressed in the SVZ both at the mRNA and protein levels. Our data suggest that stimulating endogenous SVZ neural stem cells by NPY may be of a potential interest in cell replacement based therapies of neurodegenerative diseases affecting the striatum such as Huntington's disease. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:441 / 449
页数:9
相关论文
共 45 条
[1]
NEUROPEPTIDE-Y DISTRIBUTION IN HUMAN-BRAIN
[J].
ADRIAN, TE
;
ALLEN, JM
;
BLOOM, SR
;
GHATEI, MA
;
ROSSOR, MN
;
ROBERTS, GW
;
CROW, TJ
;
TATEMOTO, K
;
POLAK, JM
.
NATURE,
1983, 306 (5943)
:584-586

ADRIAN, TE
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

ALLEN, JM
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

BLOOM, SR
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

GHATEI, MA
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

ROSSOR, MN
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

ROBERTS, GW
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

CROW, TJ
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

TATEMOTO, K
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

POLAK, JM
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND
[2]
Neuropeptide Y promotes neurogenesis in murine subventricular zone
[J].
Agasse, Fabienne
;
Bernardino, Liliana
;
Kristiansen, Heidi
;
Christiansen, Soren H.
;
Ferreira, Raquel
;
Silva, Bruno
;
Grade, Sofia
;
Woldbye, David P. D.
;
Malva, Joao O.
.
STEM CELLS,
2008, 26 (06)
:1636-1645

论文数: 引用数:
h-index:
机构:

Bernardino, Liliana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Kristiansen, Heidi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Neurosci & Pharmacol, Lab Neuropsychiat, Copenhagen, Denmark
Rigshosp Univ Hosp, Copenhagen, Denmark Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Christiansen, Soren H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Neurosci & Pharmacol, Lab Neuropsychiat, Copenhagen, Denmark
Rigshosp Univ Hosp, Copenhagen, Denmark Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Ferreira, Raquel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Silva, Bruno
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Grade, Sofia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Woldbye, David P. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Neurosci & Pharmacol, Lab Neuropsychiat, Copenhagen, Denmark
Rigshosp Univ Hosp, Copenhagen, Denmark Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal

Malva, Joao O.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Biochem,Neuroprotect & Neurogenesis Brain Re, P-3004504 Coimbra, Portugal
[3]
NEUROPEPTIDE-Y DISTRIBUTION IN THE RAT-BRAIN
[J].
ALLEN, YS
;
ADRIAN, TE
;
ALLEN, JM
;
TATEMOTO, K
;
CROW, TJ
;
BLOOM, SR
;
POLAK, JM
.
SCIENCE,
1983, 221 (4613)
:877-879

ALLEN, YS
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

ADRIAN, TE
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

ALLEN, JM
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

TATEMOTO, K
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

CROW, TJ
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

BLOOM, SR
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

POLAK, JM
论文数: 0 引用数: 0
h-index: 0
机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND
[4]
Neuronal replacement from endogenous precursors in the adult brain after stroke
[J].
Arvidsson, A
;
Collin, T
;
Kirik, D
;
Kokaia, Z
;
Lindvall, O
.
NATURE MEDICINE,
2002, 8 (09)
:963-970

Arvidsson, A
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden

Collin, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden

Kirik, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden

Kokaia, Z
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden

Lindvall, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden
[5]
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone
[J].
Baer, Kristin
;
Eriksson, Peter S.
;
Faull, Richard L. M.
;
Rees, Mark I.
;
Curtis, Maurice A.
.
EXPERIMENTAL NEUROLOGY,
2007, 204 (02)
:828-831

Baer, Kristin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales

Eriksson, Peter S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales

Faull, Richard L. M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales

Rees, Mark I.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales

Curtis, Maurice A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales
[6]
Neural transplantation for the treatment of Parkinson's disease
[J].
Björklund, A
;
Dunnett, SB
;
Brundin, P
;
Stoessl, AJ
;
Freed, CR
;
Breeze, RE
;
Levivier, M
;
Peschanski, M
;
Studer, L
;
Barker, R
.
LANCET NEUROLOGY,
2003, 2 (07)
:437-445

Björklund, A
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Dunnett, SB
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Brundin, P
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Stoessl, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Freed, CR
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Breeze, RE
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Levivier, M
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Peschanski, M
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Studer, L
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden

Barker, R
论文数: 0 引用数: 0
h-index: 0
机构: Lund Univ, Wallenberg Neurosci Ctr, Neurobiol Sect, S-22100 Lund, Sweden
[7]
Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone
[J].
Chmielnicki, E
;
Benraiss, A
;
Economides, AN
;
Goldman, SA
.
JOURNAL OF NEUROSCIENCE,
2004, 24 (09)
:2133-2142

Chmielnicki, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Rochester, Dept Neurol, Rochester, NY 14642 USA

Benraiss, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Rochester, Dept Neurol, Rochester, NY 14642 USA

Economides, AN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Rochester, Dept Neurol, Rochester, NY 14642 USA

Goldman, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Rochester, Dept Neurol, Rochester, NY 14642 USA
[8]
Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone
[J].
Coronas, V
;
Bantubungi, K
;
Fombonne, J
;
Krantic, S
;
Schiffmann, SN
;
Roger, M
.
JOURNAL OF NEUROCHEMISTRY,
2004, 91 (06)
:1292-1301

Coronas, V
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France

Bantubungi, K
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France

Fombonne, J
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France

Krantic, S
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France

Schiffmann, SN
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France

Roger, M
论文数: 0 引用数: 0
h-index: 0
机构: CNRS, Fac Sci, UMR 6187, PBSA, F-86022 Poitiers, France
[9]
A histochemical and immunohistochemical analysis of the subependymal layer in the normal and Huntington's disease brain
[J].
Curtis, MA
;
Waldvogel, HJ
;
Synek, B
;
Faull, RLM
.
JOURNAL OF CHEMICAL NEUROANATOMY,
2005, 30 (01)
:55-66

Curtis, MA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Auckland, Fac Med & Hlth Sci, Dept Anat & Radiol, Auckland 1, New Zealand

Waldvogel, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Auckland, Fac Med & Hlth Sci, Dept Anat & Radiol, Auckland 1, New Zealand

Synek, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Auckland, Fac Med & Hlth Sci, Dept Anat & Radiol, Auckland 1, New Zealand

Faull, RLM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Auckland, Fac Med & Hlth Sci, Dept Anat & Radiol, Auckland 1, New Zealand
[10]
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
[J].
Curtis, MA
;
Penney, EB
;
Pearson, AG
;
van Roon-Mom, WMC
;
Butterworth, NJ
;
Dragunow, M
;
Connor, B
;
Faull, RLM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (15)
:9023-9027

Curtis, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Penney, EB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Pearson, AG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

van Roon-Mom, WMC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Butterworth, NJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Dragunow, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Connor, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand

Faull, RLM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand Univ Auckland, Dept Pharmacol & Clin Pharmacol, Fac Med & Hlth Sci, Auckland 1, New Zealand