Potential role of type I interferons in the treatment of pituitary adenomas

被引：10

作者：

Vitale, Giovanni ^{[1
,2
]}

Caraglia, Michele ^{[3
]}

van Koetsveld, Peter M. ^{[2
]}

Maroni, Paola ^{[1
,4
]}

Marra, Monica ^{[3
]}

Colao, Annamaria ^{[5
]}

Lamberts, Steven W. J. ^{[2
]}

Cavagnini, Francesco ^{[1
]}

Hofland, Leo J. ^{[2
]}

机构：

[1] Univ Milan, Ist Auxol Italiano IRCCS, I-20095 Milan, Italy

[2] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[3] Natl Canc Inst Fdn G Pascale, Dept Expt Oncol, Expt Pharmacol Unit, Naples, Italy

[4] IRCCS, Ist Ortoped Galeazzi, Milan, Italy

[5] Univ Naples Federico II, Dept Mol & Clin Endocrinol & Oncol, Naples, Italy

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2009年 / 10卷 / 02期

关键词：

Type I interferons; Pituitary adenomas; Hypothalamic-pituitary function; ACTH; GH; CHRONIC HEPATITIS-C; CHRONIC VIRAL-HEPATITIS; GROWTH-HORMONE RELEASE; JAK-STAT PATHWAY; ADRENAL AXIS; THYROID-DISEASE; TESTOSTERONE CONCENTRATIONS; MULTIPLE-SCLEROSIS; INDUCED DEPRESSION; ALPHA-INTERFERON;

D O I：

10.1007/s11154-008-9083-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.

引用

页码：125 / 133

页数：9

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