Effector memory CD4 T cells engage myeloid cells through TNFR and CD40 to induce innate inflammation and autoimmune pathology independent of pattern recognition receptors

被引:0
|
作者
Meibers, Hannah
McDaniel, Margaret M.
Jain, Aakanksha
Chawla, Amanpreet Singh
Pasare, Chandrashekhar
机构
关键词
D O I
10.4049/jimmunol.208.Supp.164.19
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
164.19
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells
    McDaniel, Margaret M.
    Chawla, Amanpreet Singh
    Jain, Aakanksha
    Meibers, Hannah E.
    Saha, Irene
    Gao, Yajing
    Jain, Viral
    Roskin, Krishna
    Way, Sing Sing
    Pasare, Chandrashekhar
    SCIENCE IMMUNOLOGY, 2022, 7 (67) : eabk0182
  • [2] Regulation of pathogenicity through CD40 expressed on CD4 T cells
    Baker, Rocky
    Wagner, David
    Haskins, Kathryn
    CLINICAL IMMUNOLOGY, 2007, 123 : S25 - S25
  • [3] Blockade of CD40 Signaling on Diabetogenic CD4 T Cells Inhibits Effector Function
    Baker, Rocky
    Mallevaey, Thierry
    Gapin, Laurent
    Haskins, Kathrin
    CLINICAL IMMUNOLOGY, 2010, 135 : S132 - S132
  • [4] Influenza-specific memory CD4 T cells regulate acute inflammation independent of innate immune recognition
    Strutt, Tara M.
    McKinstry, K. Kai
    Dutton, Richard W.
    Swain, Susan L.
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [5] The effector to memory transition of CD4 T cells
    McKinstry, K. Kai
    Strutt, Tara M.
    Swain, Susan L.
    IMMUNOLOGIC RESEARCH, 2008, 40 (02) : 114 - 127
  • [6] The effector to memory transition of CD4 T cells
    K. Kai McKinstry
    Tara M. Strutt
    Susan L. Swain
    Immunologic Research, 2008, 40
  • [7] CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
    MacLeod, M
    Kwakkenbos, MJ
    Crawford, A
    Brown, S
    Stockinger, B
    Schepers, K
    Schumacher, T
    Gray, D
    JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) : 897 - 906
  • [8] Degenerate antigen recognition by CD4(+) effector T cells in experimental autoimmune encephalomyelitis
    McRae, BL
    Karandikar, NJ
    Miller, SD
    JOURNAL OF NEUROIMMUNOLOGY, 1997, 75 (1-2) : 156 - 162
  • [9] CD40 is a regulatory molecule on diabetogenic CD4 T-cells
    Baker, Rocky L.
    Wagner, David
    Haskins, Kathryn
    DIABETES, 2008, 57 : A352 - A352
  • [10] CD40 on NOD CD4 T cells contributes to their activation and pathogenicity
    Baker, Rocky L.
    Wagner, David H., Jr.
    Haskins, Kathryn
    JOURNAL OF AUTOIMMUNITY, 2008, 31 (04) : 385 - 392