New cytotoxic withanolides from Physalis peruviana

被引：71

作者：

Lan, Yu-Hsuan ^{[1
]}

Chang, Fang-Rong ^{[1
]}

Pan, Mei-Jung ^{[1
]}

Wu, Chin-Chung ^{[1
]}

Wu, Shu-Jing ^{[2
]}

Chen, Su-Li ^{[1
]}

Wang, Shyh-Shyan

Wu, Ming-Jung ^{[3
]}

Wu, Yang-Chang ^{[1
,4
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Chia Nan Univ Pharm & Sci, Grad Inst Nutr Hlth, Tainan 71710, Taiwan

[3] Kaohsiung Med Univ, Fac Med & Appl Chem, Kaohsiung 807, Taiwan

[4] Natl Sun Yat Sen Univ, Kaohsiung Med Univ, Joint Res Ctr, Kaohsiung 804, Taiwan

来源：

FOOD CHEMISTRY | 2009年 / 116卷 / 02期

关键词：

Physalis peruviana L; Withanolides; Phyperunolide A-F; Peruvianoxide; Cytotoxicity; ERGOSTANE-TYPE STEROIDS; WITHANIA-SOMNIFERA; 4BETA-HYDROXYWITHANOLIDE-E;

D O I：

10.1016/j.foodchem.2009.02.061

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4), peruvianoxide (5), phyperunolide E (16), and phyperunolide F (17) together with ten known withanolides. The structure and absolute stereochemistry of all compounds were elucidated on the basis of CID and NMR spectral analysis, respectively. Compounds 1, 6, 7, and 9 showed cytotoxicity against lung cancer (A549), breast cancer (MDA-MB-231 and MCF7), and liver cancer (Hep G2 and Hep 3B) cancer cell lines. The presence of 5 beta,6 beta-epoxy-2-en-1-ones in withanolides is greatly helpful in cytotoxicity, it is a key known important factor to cytotoxicity: however, interestingly, the unusual 5-chloride withanolide, 9, displayed significant activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：462 / 469

页数：8

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