Syntheses and biological activities of the proposed structure of apteniol A and its derivatives

被引：3

作者：

Nishikawa, Hikaru ^{[1
]}

Noshita, Toshiro ^{[2
]}

Tai, Akihiro ^{[2
]}

Ouchi, Hidekazu ^{[3
]}

Okamoto, Taisuke ^{[4
]}

Saito, Akiko ^{[4
,5
]}

Yamada, Teiko ^{[6
]}

Iomori, Atsuko ^{[1
]}

Ishimata, Nao ^{[2
]}

机构：

[1] Prefectural Univ Hiroshima, Grad Sch Comprehens Sci Res, Program Biol Syst Sci, Shobara, Japan

[2] Prefectural Univ Hiroshima, Fac Life & Environm Sci, Dept Life Sci, Shobara, Japan

[3] Kinki Univ, Fac Pharmaceut Educ, Dept Pharm, Higashiosaka, Osaka 577, Japan

[4] Osaka Electrocommun Univ, Grad Sch Engn, Neyagawa, Osaka 572, Japan

[5] Osaka Electrocommun Univ, Fac Engn, Dept Environm Sci, Neyagawa, Osaka 572, Japan

[6] Tohoku Univ, Dept Biosci & Biotechnol Future Bioind, Grad Sch Agr Sci, Sendai, Miyagi 980, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 09期

关键词：

Aptenia cordifolia; oxyneolignan; Ullmann ether synthesis; apteniol; PIPERAZINOMYCIN; CORDIFOLIA; INHIBITORS; CELLS;

D O I：

10.1080/09168451.2014.930322

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.

引用

页码：1485 / 1489

页数：5

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