Syntheses and biological activities of the proposed structure of apteniol A and its derivatives

被引：3
|
作者：
Nishikawa, Hikaru [1 ]
Noshita, Toshiro [2 ]
Tai, Akihiro [2 ]
Ouchi, Hidekazu [3 ]
Okamoto, Taisuke [4 ]
Saito, Akiko [4 ,5 ]
Yamada, Teiko [6 ]
Iomori, Atsuko [1 ]
Ishimata, Nao [2 ]
机构：
[1] Prefectural Univ Hiroshima, Grad Sch Comprehens Sci Res, Program Biol Syst Sci, Shobara, Japan
[2] Prefectural Univ Hiroshima, Fac Life & Environm Sci, Dept Life Sci, Shobara, Japan
[3] Kinki Univ, Fac Pharmaceut Educ, Dept Pharm, Higashiosaka, Osaka 577, Japan
[4] Osaka Electrocommun Univ, Grad Sch Engn, Neyagawa, Osaka 572, Japan
[5] Osaka Electrocommun Univ, Fac Engn, Dept Environm Sci, Neyagawa, Osaka 572, Japan
[6] Tohoku Univ, Dept Biosci & Biotechnol Future Bioind, Grad Sch Agr Sci, Sendai, Miyagi 980, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 09期
关键词：
Aptenia cordifolia; oxyneolignan; Ullmann ether synthesis; apteniol; PIPERAZINOMYCIN; CORDIFOLIA; INHIBITORS; CELLS;
D O I：
10.1080/09168451.2014.930322
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.
引用
收藏
页码：1485 / 1489
页数：5
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