Prognostic factors in stage IB gastric cancer

被引：20

作者：

Aoyama, Toru ^{[1
]}

Yoshikawa, Takaki ^{[1
]}

Fujikawa, Hirohito ^{[1
]}

Hayashi, Tsutomu ^{[1
]}

Ogata, Takashi ^{[1
]}

Cho, Haruhiko ^{[1
]}

Yamada, Takanobu ^{[2
]}

Hasegawa, Shinichi ^{[2
]}

Tsuchida, Kazuhito ^{[2
]}

Yukawa, Norio ^{[2
]}

Oshima, Takashi ^{[2
]}

Oba, Mari S. ^{[3
]}

Morita, Satoshi ^{[3
]}

Rino, Yasushi ^{[2
]}

Masuda, Munetaka

机构：

[1] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa 2410815, Japan

[2] Yokohama City Univ, Dept Surg, Yokohama, Kanagawa 2360004, Japan

[3] Yokohama City Univ, Dept Biostat & Epidemiol, Yokohama, Kanagawa 2360004, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 21期

关键词：

Gastric cancer; Stage IB; Prognostic factor; ADJUVANT CHEMOTHERAPY; S-1; RECURRENCE; TRIAL;

D O I：

10.3748/wjg.v20.i21.6580

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To identify the subset of patients with stage IB gastric cancer with an unfavorable prognosis. METHODS: Overall survival (OS) rates were examined in 103 patients with stage IB (T1N1M0 and T2N0M0) gastric cancer between January 2000 and December 2011. Univariate and multivariate analyses were performed to identify risk factors using a Cox proportional hazards model. RESULTS: The OS rates of patients with T1N1 and T2N0 cancer were 89.2% and 94.1% at 5-years, respectively. Both univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic factor. The OS rate was 81.8% at 5-years when the tumor was located in the upper third of the stomach and was 95.5% at 5-years when the tumor was located in the middle or lower third of the stomach (P = 0.0093). CONCLUSION: These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：6580 / 6585

页数：6

共 14 条

[1] Evaluation of the Seventh American Joint Committee on Cancer/International Union Against Cancer Classification of Gastric Adenocarcinoma in Comparison With the Sixth Classification [J].

Ahn, Hye Seong ;

Lee, Hyuk Joon ;

Hahn, Seokyung ;

Kim, Woo Ho ;

Lee, Kuhn Uk ;

Sano, Takeshi ;

Edge, Stephen B. ;

Yang, Han-Kwang .

CANCER, 2010, 116 (24) :5592-5598

[2] Risk Factors for Peritoneal Recurrence in Stage II/III Gastric Cancer Patients Who Received S-1 Adjuvant Chemotherapy After D2 Gastrectomy [J].

Aoyama, Toru ;

Yoshikawa, Takaki ;

Hayashi, Tsutomu ;

Kuwabara, Hiroshi ;

Mikayama, Yo ;

Ogata, Takashi ;

Cho, Haruhiko ;

Tsuburaya, Akira .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (05) :1568-1574

[3] Macroscopic tumor size as an independent prognostic factor for stage II/III gastric cancer patients who underwent D2 gastrectomy followed by adjuvant chemotherapy with S-1 [J].

Aoyama, Toru ;

Yoshikawa, Takaki ;

Watanabe, Takafumi ;

Hayashi, Tsutomu ;

Ogata, Takashi ;

Cho, Haruhiko ;

Tsuburaya, Akira .

GASTRIC CANCER, 2011, 14 (03) :274-278

[4] Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study [J].

Boku, Narikazu ;

Yamamoto, Seiichiro ;

Fukuda, Haruhiko ;

Shirao, Kuniaki ;

Doi, Toshihiko ;

Sawaki, Akira ;

Koizumi, Wasaburo ;

Saito, Hiroshi ;

Yamaguchi, Kensei ;

Takiuchi, Hiroya ;

Nasu, Junichiro ;

Ohtsu, Atsushi .

LANCET ONCOLOGY, 2009, 10 (11) :1063-1069

[5] Japanese classification of gastric carcinoma: 3rd English edition [J].

Sano T. ;

Kodera Y. .

GASTRIC CANCER, 2011, 14 (02) :101-112

[6] Japanese gastric cancer treatment guidelines 2010 (ver. 3) [J].

Sano T. ;

Kodera Y. .

GASTRIC CANCER, 2011, 14 (02) :113-123

[7] S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial [J].

Koizumi, Wasaburo ;

Narahara, Hiroyuki ;

Hara, Takuo ;

Takagane, Akinori ;

Akiya, Toshikazu ;

Takagi, Masakazu ;

Miyashita, Kosei ;

Nishizaki, Takashi ;

Kobayashi, Osamu ;

Takiyama, Wataru ;

Toh, Yasushi ;

Nagaie, Takashi ;

Takagi, Seiichi ;

Yamamura, Yoshitaka ;

Yanaoka, Kimihiko ;

Orita, Hiroyuki ;

Takeuchi, Masahiro .

LANCET ONCOLOGY, 2008, 9 (03) :215-221

[8] Disparities in gastric cancer chemotherapy between the East and West [J].

Ohtsu, Atsushi ;

Yoshida, Shigeaki ;

Saijo, Nagahiro .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (14) :2188-2196

[9] Proximal versus distal gastric carcinoma - What are the differences? [J].

Piso, P ;

Werner, U ;

Lang, H ;

Mirena, P ;

Klempnauer, J .

ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (07) :520-525

[10] Recurrence in early gastric cancer with lymph node metastasis [J].

Saka, Makoto ;

Katai, Hitoshi ;

Fukagawa, Takeo ;

Nijjar, Rajwinder ;

Sano, Takeshi .

GASTRIC CANCER, 2008, 11 (04) :214-218

← 1 2 →