Synthesis of Coumarin linked Naphthalimide Conjugates as Potential Anticancer and Antimicrobial Agents

被引：56

作者：

Kamal, Ahmed ^{[1
]}

Adil, S. F. ^{[1
]}

Tamboli, Jaki R. ^{[1
]}

Siddardha, B. ^{[2
]}

Murthy, U. S. N. ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Biol Chem Lab, Div Organ Chem, Hyderabad 500067, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500067, Andhra Pradesh, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 03期

关键词：

Coumarin-thaizolyl; Naphthalimide; Anticancer; Antimicrobial; DNA binding affinity; DNA-BINDING AGENTS; ANTITUMOR AGENTS; HYBRIDS; CYTOTOXICITY; DERIVATIVES; INHIBITORS; DESIGN; ASSAY;

D O I：

10.2174/157018009787847855

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new coumarin linked naphthalimides (16a-g; 18a-g) was synthesised and evaluated for their in vitro anticancer activity against six cancer cell lines. Most of the compounds investigated have shown good to moderate anticancer activity against colon, breast and lung cancer cell lines. Thermal denaturation studies indicated that some compounds exhibited DNA binding ability. They were also found to be active against gram-positive and gram-negative bacterial strains as well as a few fungal strains.

引用

页码：201 / 209

页数：9

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