S100 family signaling network and related proteins in pancreatic cancer (Review)

被引：80

作者：

Ji, Yi-Fei ^{[1
]}

Huang, Hua ^{[2
]}

Jiang, Feng ^{[1
]}

Ni, Run-Zhou ^{[1
]}

Xiao, Ming-Bing ^{[1
]}

机构：

[1] Nantong Univ, Dept Gastroenterol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

[2] Nantong Univ, Dept Pathol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2014年 / 33卷 / 04期

关键词：

molecular targets; S100; proteins; pancreatic cancer; expression; biomarkers; CALCIUM-MODULATED PROTEINS; LIVER METASTASIS; BINDING PROTEINS; GENE-EXPRESSION; DOWN-REGULATION; CELL-SURVIVAL; TUMOR-GROWTH; P53; TARGET; PROGRESSION;

D O I：

10.3892/ijmm.2014.1633

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The occurrence and development of pancreatic cancer is a complex process convoluted by multi-pathogenies, multi-stages and multi-factors. S100 proteins are members of the S100 family that regulate multiple cellular pathways related to pancreatic cancer progression and metastasis. S100 proteins have a broad range of intracellular and extracellular functions, including the regulation of protein phosphorylation and enzyme activity, calcium homeostasis and the regulation of cytoskeletal components and transcriptional factors. S100 proteins interact with receptor for advanced glycation end-products (RAGE), p53 and p21, which play a role in the degradation of the extracellular matrix (ECM) and metastasis, and also interact with cytoskeletal proteins and the plasma membrane in pancreatic cancer progression and metastasis. S100A11 and S100P are significant tumor markers for pancreatic cancer and unfavorable predictors for the prognosis of patients who have undergone surgical resection. Recently, S100A2 has been suggested to be a negative prognostic biomarker in pancreatic cancer, and the expression of S100A6 may be an independent prognostic impact factor. The expression of S100A4 and S100P is associated with drug resistance, differentiation, metastasis and clinical outcome. This review summarizes the role and significance of the S100 family signaling network and related proteins in pancreatic cancer.

引用

页码：769 / 776

页数：8

共 91 条

[1]

[Anonymous], J CLIN ONCOL S4

[2] S100P promotes pancreatic cancer growth, survival, and invasion [J].

Arumugam, T ;

Simeone, DM ;

Van Golen, K ;

Logsdon, CD .

CLINICAL CANCER RESEARCH, 2005, 11 (15) :5356-5364

[3] Designing and Developing S100P Inhibitor 5-Methyl Cromolyn for Pancreatic Cancer Therapy [J].

Arumugam, Thiruvengadam ;

Ramachandran, Vijaya ;

Sun, Duoli ;

Peng, Zhenghong ;

Pal, Ashutosh ;

Maxwell, David S. ;

Bornmann, William G. ;

Logsdon, Craig D. .

MOLECULAR CANCER THERAPEUTICS, 2013, 12 (05) :654-662

[4] S100P-Derived RAGE Antagonistic Peptide Reduces Tumor Growth and Metastasis [J].

Arumugam, Thiruvengadam ;

Ramachandran, Vijaya ;

Gomez, Sobeyda B. ;

Schmidt, Ann M. ;

Logsdon, Craig D. .

CLINICAL CANCER RESEARCH, 2012, 18 (16) :4356-4364

[5] S100P: a novel therapeutic target for cancer [J].

Arumugam, Thiruvengadam ;

Logsdon, Craig D. .

AMINO ACIDS, 2011, 41 (04) :893-899

[6] S100A2 is a predictive biomarker of adjuvant therapy benefit in pancreatic adenocarcinoma [J].

Bachet, Jean-Baptiste ;

Marechal, Raphael ;

Demetter, Pieter ;

Bonnetain, Franck ;

Cros, Jerome ;

Svrcek, Magali ;

Bardier-Dupas, Armelle ;

Hammel, Pascal ;

Sauvanet, Alain ;

Louvet, Christophe ;

Paye, Francois ;

Vaillant, Jean-Christophe ;

Andre, Thierry ;

Closset, Jean ;

Salmon, Isabelle ;

Emile, Jean-Francois ;

Van Laethem, Jean-Luc .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (12) :2643-2653

[7] S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [J].

Barry, Sayka ;

Chelala, Claude ;

Lines, Kate ;

Sunamura, Makoto ;

Wang, Amu ;

Marelli-Berg, Federica M. ;

Brennan, Caroline ;

Lemoine, Nicholas R. ;

Crnogorac-Jurcevic, Tatjana .

CLINICAL & EXPERIMENTAL METASTASIS, 2013, 30 (03) :251-264

[8] Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53 [J].

Berge, Gisle ;

Mlandsmo, Gunhild M. .

AMINO ACIDS, 2011, 41 (04) :863-873

[9] Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer [J].

Biankin, Andrew V. ;

Kench, James G. ;

Colvin, Emily K. ;

Segara, Davendra ;

Scarlett, Christopher J. ;

Nguyen, Nam Q. ;

Chang, David K. ;

Morey, Adrienne L. ;

Lee, C. -Soon ;

Pinese, Mark ;

Kuo, Samuel C. L. ;

Susanto, Johana M. ;

Cosman, Peter H. ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. ;

Nguyen, Tuan V. ;

Merrett, Neil D. ;

Warusavitarne, Janindra ;

Musgrove, Elizabeth A. ;

Henshall, Susan M. ;

Sutherland, Robert L. .

GASTROENTEROLOGY, 2009, 137 (02) :558-568

[10] Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection [J].

Brain, J. G. ;

Robertson, H. ;

Thompson, E. ;

Humphreys, E. H. ;

Gardner, A. ;

Booth, T. A. ;

Jones, D. E. J. ;

Afford, S. C. ;

von Zglinicki, T. ;

Burt, A. D. ;

Kirby, J. A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (07) :1688-1702

← 1 2 3 4 5 6 7 8 9 10 →