Model-free analysis and permutation tests for allelic associations

被引：353

作者：

Zhao, JH

Curtis, D

Sham, PC

机构：

[1] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England

[2] St Bartholomews & Royal London Sch Med & Dent, Joint Acad Dept Psychol Med, London, England

来源：

HUMAN HEREDITY | 2000年 / 50卷 / 02期

关键词：

case-control design; allelic association; haplotype analysis; permutation test; model-free association analysis;

D O I：

10.1159/000022901

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this short report, we address some practical problems in performing likelihood-based allelic association analysis of case-control data. Model-free statistics are proposed and their properties assessed by simulation, and procedures based on permutation tests a re described for marker-marker as well as marker-disease associations. A memory-efficient algorithm is developed which enables several highly polymorphic markers to be analysed. Copyright (C) 1999 S. Karger AG, Basel.

引用

页码：133 / 139

页数：7

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