Identification of a locus for susceptibility to renal cell carcinoma in the Long-Evans Cinnamon rat

被引：0

作者：

Wei, K

Izumi, K

Hino, A

Wei, SW

Sasaki, Y

Yamada, T

Matsumoto, K

机构：

[1] Univ Tokushima, Sch Med, Inst Anim Experimentat, Tokushima 7708503, Japan

[2] Univ Tokushima, Sch Med, Dept Pathol 2, Tokushima 7708503, Japan

[3] Kyoto Univ, Grad Sch Agr, Lab Anim Genet & Breeding, Sakyo Ku, Kyoto 6068224, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1999年 / 61卷 / 11期

关键词：

LEC rat; linkage; renal cell carcinoma;

D O I：

10.1292/jvms.61.1261

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The Long-Evans Cinnamon (LEC) mutant rat shows higher incidence of renal cell carcinomas induced by a treatment with the chemical carcinogen N-diethylnitrosamine, as compared to the normal control rat. We performed the first genome-wide scan for genes responsible for susceptibility to chemically induced renal cell carcinoma in an F-2 intercross obtained by mating the LEC and Fischer-344 (F344) rats. The genotype of 71 (F344 x LEG) F-2 progenies was determined with the use of 338 simple sequence length polymorphisms (SSLPs) spread over the genome. The F-2 rats which carried renal cell carcinoma were shown to possess the incidence of homozygosity of the LEC allele which is higher than that of the other genotypes at SSLP markers on chromosome 5 (chi(2) = 17.5 for D5Rat21). Our linkage analysis has led to the revelation of a novel gene that influences susceptibility to renal cell carcinoma on rat chromosome 5.

引用

页码：1261 / 1264

页数：4

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