Surface reconstruction and hemocompatibility improvement of a phosphorylcholine end-capped poly(butylene succinate) coating

被引:23
作者
Hao, Ni [1 ,2 ]
Wang, Yan-Bing [1 ,2 ]
Zhang, Shi-Ping [1 ,2 ]
Shi, Su-Qing [1 ,2 ]
Nakashima, Kenichi [3 ]
Gong, Yong-Kuan [1 ,2 ]
机构
[1] NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China
[2] NW Univ Xian, Coll Chem & Mat Sci, Xian 710069, Shaanxi, Peoples R China
[3] Saga Univ, Dept Chem, Saga 840, Japan
基金
中国国家自然科学基金;
关键词
surface reconstruction; poly(butylene succinate); phosphorylcholine; hemocompatibility; contact angle; PROTEIN ADSORPTION-RESISTANCE; BEARING PHOSPHORYLCHOLINE; CELL-ADHESION; POLYMERS; COPOLYMERS; PLASMA; BIOCOMPATIBILITY; MECHANISM; DYNAMICS; CHAIN;
D O I
10.1002/jbm.a.34967
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Control over cell-material surface interactions is the key to many new and improved biomedical devices. In this study, we present a simple yet effective surface modification method that allows for the surface reconstruction and formation of cell outer membrane mimetic structure on coatings that have significantly increased hemocompatibility. To achieve this, a phosphorylcholine end-capped poly(butylene succinate) (PBS-PC) was synthesized and dip-coated on coverslips. The surface structure of the amphiphilic PBS-PC film was reconstructed by heating in a vacuum oven to obtain the less hydrophilic surface and by immersing in hot water to obtain the more hydrophilic surface. Significant changes in the surface element concentration were observed by X-ray photoelectron spectroscopy analysis and changes in surface wettability were measured by sensitive dynamic contact angle technique. Scanning electron microscope images showed different morphologies of the reconstructed surfaces. Interestingly, the reconstruction between the less hydrophilic and more hydrophilic surfaces is reversible. More importantly, both the reconstructed surfaces are stable in room condition for more than 6 months, and both the surfaces show significant improvement in hemocompatibility as revealed by protein adsorption and platelet adhesion measurements. This reversible surface reconstruction strategy and the interesting results may be significant for fabricating stable and hemocompatible surfaces on differently shaped biomedical devices. (C) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:2972 / 2981
页数:10
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