Antidiabetic potential of Balanites Aegyptiaca kernel, flesh and their combination against streptozotocin-induced hyperglycemia in male rats

被引:2
作者
Al-Thobaiti, Saed A. [1 ]
Abu Zeid, Isam M. [1 ]
机构
[1] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, POB 139109, Jeddah 21323, Saudi Arabia
关键词
Balanites aegyptiaca; Diabetes; Histopathology; Insulin; Pancreas; IN-VITRO; PREVALENCE; MANAGEMENT; EXTRACT; LIVER;
D O I
10.4314/tjpr.v18i2.7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose: To investigate the antidiabetic effect of Balanites aegyptiaca fruit kernel, flesh and their mixture on streptozocin (STZ)-induced diabetes in male rats. Methods: Six-week-old male Wistar rats were divided into nine groups: (1) control; (2) kernel; (3) flesh; (4) kernel + flesh; (5) STZ; (6) STZ + kernel; (7) STZ + flesh; (8) STZ + (kernel + flesh) and (9) STZ + metformin. Body weight changes, fasting blood glucose and serum insulin were assessed. Haematoxylin and Eosin (H & E) stained pancreas sections were examined microscopically for the number and status of beta cells. Results: Administration of Balanites aegyptiaca kernel, flesh and their mixture significantly increased rat body weight compared to STZ-treated rats. In addition, the hypoglycemic effect of kernel, flesh and their mixture was noticed. In STZ-treated rats, administration of Balanites aegyptiaca kernel and kernel + flesh mixture significantly increased serum insulin (p < 0.05). Histopathological examination revealed a marked increase in the islets cell population with cellular activation, with superior effect in STZ + kernel group and STZ + (kernel + flesh) group. Conclusion: Balanites aegyptiaca showed a hypoglycemic effect which is comparable to metformin action. Further studies are required to determine its suitability as an anti-diabetic agent in humans
引用
收藏
页码:263 / 271
页数:9
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