YAP1 Takes Over when Oncogenic K-Ras Slumbers

被引：22

作者：

Greten, Florian R. ^{[1
]}

机构：

[1] Inst Tumor Biol & Expt Therapy, Georg Speyer Haus, D-60596 Frankfurt, Germany

来源：

CELL | 2014年 / 158卷 / 01期

关键词：

THERAPY; KRAS;

D O I：

10.1016/j.cell.2014.06.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.

引用

页码：11 / 12

页数：2

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