Implications of chimaeric non-co-linear transcripts

被引：163

作者：

Gingeras, Thomas R. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE | 2009年 / 461卷 / 7261期

关键词：

LONG NONCODING RNAS; HUMAN GENOME; SPLICED LEADER; MESSENGER-RNAS; FUNCTIONAL ELEMENTS; PROSTATE-CANCER; GENE FUSION; SEQUENCE; SITES; IDENTIFICATION;

D O I：

10.1038/nature08452

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Deep sequencing of 'transcriptomes' - the collection of all RNA transcripts produced at a given time - from worms to humans reveals that some transcripts are composed of sequence segments that are not co-linear, with pieces of sequence coming from distant regions of DNA, even different chromosomes. Some of these 'chimaeric' transcripts are formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are not. The existence of such chimaeric RNAs has far-reaching implications for the potential information content of genomes and the way it is arranged.

引用

页码：206 / 211

页数：6

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