Preparation and characterization of crosslinked chitosan/gelatin scaffolds by ice segregation induced self-assembly

被引：143

作者：

Nieto-Suarez, Marina ^{[1
,2
]}

Arturo Lopez-Quintela, M. ^{[2
]}

Lazzari, Massimo ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Ctr Res Biol Chem & Mol Mat CIQUS, Campus Vida, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Dept Phys Chem, Fac Chem, Santiago De Compostela 15782, Spain

来源：

CARBOHYDRATE POLYMERS | 2016年 / 141卷

关键词：

Chitosan; Gelatin; Hydrogel; Scaffold; Unidirectional freezing; Biomaterial; GELATIN SCAFFOLDS; HYDROGELS; CHITIN; LINKING; MORPHOLOGY; GELS; CARTILAGE; POLYMERS; REPAIR; NERVE;

D O I：

10.1016/j.carbpol.2015.12.064

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chitosan and gelatin are biodegradable and biocompatible polymers which may be used in the preparation of 3D scaffolds with applications in biomedicine. Chitosan/gelatin scaffolds crosslinked with glutaraldehyde were prepared by ice segregation induced self-assembly (ISISA); a unidirectional freezing at -196 degrees C followed freeze-drying to produce macroporous materials with a well-patterned structure. This process may be included within the green chemistry by the preparation of the porous structures without using organic solvents, moreover is a versatile, non-difficult and cheap process. The scaffolds prepared by ISISA were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, and their stability was evaluated by degree swelling and degradation tests. The scaffolds present properties as high porosity, high degree swelling and good stability which make them suitable of applications as biomaterials. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：175 / 183

页数：9

共 63 条

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