Complete genome sequence of Bacillus thuringiensis L-7601, a wild strain with high production of melanin

被引:15
作者
Cao, Zhang-lei [1 ]
Tan, Tong-tong [1 ]
Jiang, Kun [1 ]
Mei, Si-qi [1 ]
Hou, Xiao-yue [1 ]
Cai, Jun [1 ,2 ]
机构
[1] Nankai Univ, Dept Microbiol, Coll Life Sci, Tianjin 300071, Peoples R China
[2] Minist Educ, Key Lab Mol Microbiol & Technol, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金;
关键词
Bacillus thuringiensis; Melanin biosynthesis pathway; hmgA; Frameshift mutant; Complete genome; PIGMENT; MUTANT;
D O I
10.1016/j.jbiotec.2018.03.020
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bacillus thuringiensis L-7601 (B. thuringiensis L-7601), belonging to Bacillus thuringiensis subsp. dendrolimus serotype H4a4b, is a wild-type strain which has the ability to produce melanin during the exponential phase of growth. The melanin produced is an excellent UV protective agent for the crystal insecticidal proteins. Here, we report the complete genome of B. thuringiensis L-7601 including one 5,790,408 bp chromosome and three plasmids. 6,519 CDSs and 150 RNA genes, including 106 tRNA genes, 39 rRNA genes and 5 ncRNA genes, were identified from the whole genome. In addition, our results indicated that homogentisic acid pathway is the melanogenic pathway in B. thuringiensis and accumulation of melanin is the consequence of hmgA frameshift mutant.
引用
收藏
页码:40 / 43
页数:4
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