Optimal timing of [18F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

被引：3
|
作者：
Lee, Jae-Hoon [1 ]
Ryu, Young Hoon [1 ]
Lyoo, Chul Hyoung [2 ]
Choi, Soo-Hee [3 ,4 ]
Kim, Jae-Jin [5 ,6 ]
Choi, Jae Yong [1 ]
机构：
[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Nucl Med, Seoul, South Korea
[2] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Neurol, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Inst Human Behav Sci, Seoul, South Korea
[5] Yonsei Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[6] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul, South Korea
来源：
APPLIED RADIATION AND ISOTOPES | 2016年 / 107卷
关键词：
F-18]Mefway; Serotonin 1A receptor; Positron emission tomography; Optimal acquisition time; Standardized uptake value ratio; 5-HT1A RECEPTORS; BINDING; RADIOLIGAND;
D O I：
10.1016/j.apradiso.2015.10.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
To determine the optimal acquisition time of [F-18]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40 min and there was a strong correlation between DVR and SUVR in the 60-80 min. Therefore, we recommend the use of a single time point between 60 and 80 min for [F-18]Mefway static PET. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：127 / 132
页数：6
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