Polyunsaturated fatty acids and neurological diseases

被引：20
作者：
Salvati, S. [1 ]
Attorri, L. [1 ]
Di Benedetto, R. [1 ]
Di Biase, A. [1 ]
Leonardi, F. [1 ]
机构：
[1] Ist Super Sanita, Dept Food Nutr & Hlth, I-00161 Rome, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期
关键词：
docosahexaenoic acid; eicosapentaenoic acid; arachidonic acid; neurodegenerative diseases; Alzheimer's disease; multiple sclerosis; depression; Parkinson's disease;
D O I：
10.2174/138955706778742740
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This review summarizes the knowledge of the role of dietary PUFAs, especially omega-3, on normal brain function. Furthermore, it reports the evidence pointing to potential mechanisms of omega-3 fatty acids in development of neurological disorders and efficacy of their supplementation in terms of symptom management.
引用
收藏
页码：1201 / 1211
页数：11
相关论文
共 120 条
[11]   Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease [J].
Calon, F ;
Lim, GP ;
Morihara, T ;
Yang, FS ;
Ubeda, O ;
Salem, N ;
Frautschy, SA ;
Cole, GM .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (03) :617-626
[12]   Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model [J].
Calon, F ;
Lim, GP ;
Yang, FS ;
Morihara, T ;
Teter, B ;
Ubeda, O ;
Rostaing, P ;
Triller, A ;
Salem, N ;
Ashe, KH ;
Frautschy, SA ;
Cole, GM .
NEURON, 2004, 43 (05) :633-645
[13]  
Carrié I, 2000, J LIPID RES, V41, P465
[14]   Lipid signaling: Sleep, synaptic plasticity, and neuroprotection [J].
Chen, C ;
Bazan, NG .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2005, 77 (1-4) :65-76
[15]   Dietary intakes of fat and risk of Parkinson's disease [J].
Chen, H ;
Zhang, SMM ;
Hernán, MA ;
Willett, WC ;
Ascherio, A .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (11) :1007-1014
[16]  
Crawford MA, 2000, AM J CLIN NUTR, V71, p275S, DOI 10.1093/ajcn/71.1.275S
[17]   NMDA receptor subunits: diversity, development and disease [J].
Cull-Candy, S ;
Brickley, S ;
Farrant, M .
CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (03) :327-335
[18]   Alzheimer disease [J].
Cummings, JL ;
Cole, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (18) :2335-2338
[19]   Dietary fatty acids and the risk of Parkinson disease - The Rotterdam study [J].
de Lau, LML ;
Bornebroek, M ;
Witteman, JCM ;
Hofman, A ;
Koudstaal, PJ ;
Breteler, MMB .
NEUROLOGY, 2005, 64 (12) :2040-2045
[20]  
de Urquiza AM, 2000, SCIENCE, V290, P2140, DOI 10.1126/science.290.5499.2140
12345678910