Adipose tissue mass can be regulated through the vasculature

被引：638
作者：
Rupnick, MA
Panigrahy, D
Zhang, CY
Dallabrida, SM
Lowell, BB
Langer, R
Folkman, MJ
机构：
[1] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02115 USA
[3] Childrens Hosp, Div Surg Res, Boston, MA 02115 USA
[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 16期
关键词：
D O I：
10.1073/pnas.162349799
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tumor growth is angiogenesis dependent. We hypothesized that nonneoplastic tissue growth also depends on neovascularization. We chose adipose tissue as an experimental system because of its remodeling capacity. Mice from different obesity models received anti-angiogenic agents. Treatment resulted in dose-dependent, reversible weight reduction and adipose tissue loss. Marked vascular remodeling was evident in adipose tissue sections, which revealed decreased endothelial proliferation and increased apoptosis in treated mice compared with controls. Continuous treatment maintained mice near normal body weights for age without adverse effects. Metabolic adaptations in food intake, metabolic rate, and energy substrate utilization were associated with anti-angiogenic weight loss. We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.
引用
收藏
页码：10730 / 10735
页数：6
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