Central nervous system control of food intake and body weight

被引：1898
作者：
Morton, G. J.
Cummings, D. E.
Baskin, D. G.
Barsh, G. S.
Schwartz, M. W. [1 ]
机构：
[1] Harborview Med Ctr, Dept Med, Seattle, WA 98104 USA
[2] Univ Washington, Dept Med, Seattle, WA 98104 USA
[3] Vet Affairs Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA
[4] Univ Washington, Dept Biol Struct, Seattle, WA 98104 USA
[5] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[6] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA
来源：
NATURE | 2006年 / 443卷 / 7109期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature05026
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
引用
收藏
页码：289 / 295
页数：7
相关论文
共 75 条
[1]   AMP-activated protein kinase plays a role in the control of food intake [J].
Andersson, U ;
Filipsson, K ;
Abbott, CR ;
Woods, A ;
Smith, K ;
Bloom, SR ;
Carling, D ;
Small, CJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12005-12008
[2]   Leptin receptor signaling in is required for normal body POW neurons weight homeostasis [J].
Balthasar, N ;
Coppari, R ;
McMinn, J ;
Liu, SM ;
Lee, CE ;
Tang, V ;
Kenny, CD ;
McGovern, RA ;
Chua, SC ;
Elmquist, JK ;
Lowell, BB .
NEURON, 2004, 42 (06) :983-991
[3]   Gut hormone PYY3-36 physiologically inhibits food intake [J].
Batterham, RL ;
Cowley, MA ;
Small, CJ ;
Herzog, H ;
Cohen, MA ;
Dakin, CL ;
Wren, AM ;
Brynes, AE ;
Low, MJ ;
Ghatei, MA ;
Cone, RD ;
Bloom, SR .
NATURE, 2002, 418 (6898) :650-654
[4]   Mind versus metabolism in the control of food intake and energy balance [J].
Berthoud, HR .
PHYSIOLOGY & BEHAVIOR, 2004, 81 (05) :781-793
[5]   Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype [J].
Bewick, GA ;
Gardiner, JV ;
Dhillo, WS ;
Kent, AS ;
White, NE ;
Webster, Z ;
Ghatei, MA ;
Bloom, SR .
FASEB JOURNAL, 2005, 19 (10) :1680-+
[6]   Divergent signaling capacities of the long and short isoforms of the leptin receptor [J].
Bjorbaek, C ;
Uotani, S ;
da Silva, B ;
Flier, JS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32686-32695
[7]   Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size [J].
Blevins, JE ;
Schwartz, MW ;
Baskin, DG .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (01) :R87-R96
[8]   Role of brain insulin receptor in control of body weight and reproduction [J].
Brüning, JC ;
Gautam, D ;
Burks, DJ ;
Gillette, J ;
Schubert, M ;
Orban, PC ;
Klein, R ;
Krone, W ;
Müller-Wieland, D ;
Kahn, CR .
SCIENCE, 2000, 289 (5487) :2122-2125
[9]   FOOD-DEPRIVATION INCREASES ORAL AND INTRAVENOUS DRUG INTAKE IN RATS [J].
CARROLL, ME ;
FRANCE, CP ;
MEISCH, RA .
SCIENCE, 1979, 205 (4403) :319-321
[10]  
Choudhury AI, 2005, J CLIN INVEST, V115, P940
12345678