Hepatitis B core-related antigen to detect hepatitis B virus (HBV) reactivation in heart transplant recipients with past HBV infection: A pilot study

被引：4

作者：

Iossa, Domenico ^{[1
]}

Vitrone, Martina ^{[1
]}

Liotti, Antonietta ^{[2
]}

Portella, Giuseppe ^{[2
]}

Durante-Mangoni, Emanuele ^{[1
,3
]}

Zampino, Rosa ^{[1
,3
]}

机构：

[1] Univ Campania L Vanvitelli, Internal Med, Naples, Italy

[2] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy

[3] Monaldi Hosp, AORN Colli, Unit Infect & Transplant Med, Naples, Italy

来源：

CLINICAL TRANSPLANTATION | 2019年 / 33卷 / 06期

关键词：

HBV reactivation; heart transplant; hepatitis B core-related antigen;

D O I：

10.1111/ctr.13574

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Hepatitis B core-related antigen (HBcrAg) has been proposed as a new marker of hepatitis B virus (HBV) replication. We analyzed HBcrAg dynamics in 15 heart transplant recipients with active or prior HBV infection and correlated it with quantitative (QT)-HBsAg and HBV-DNA pre- and post-transplant. Serum HBcrAg was detected in HBsAg/HBV-DNA-positive subjects but not in recipients with past HBV infection. HBcrAg levels correlated with QT-HBsAg in pre- and post-transplant samples. In prior HBV infection, HBcrAg levels were unrelated to HBV-DNA positivity. In heart transplant recipients with prior HBV infection, HBcrAg does not correlate with viral replication and cannot be applied to detect HBV reactivation during follow-up.

引用

页数：4

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