Polymorphism of prion protein gene in Arctic fox (Vulpes lagopus)

被引：5

作者：

Wan, Jiayu ^{[1
]}

Bai, Xue ^{[1
]}

Liu, Wensen ^{[1
]}

Xu, Jing ^{[1
]}

Xu, Ming ^{[1
]}

Gao, Hongwei ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Mil Vet, Changchun 130062, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2009年 / 36卷 / 06期

关键词：

Arctic fox; Polymorphism; Prnp; CREUTZFELDT-JAKOB-DISEASE; TRANSMISSIBLE MINK ENCEPHALOPATHY; EXPERIMENTAL-INFECTION; NATURAL SCRAPIE; SHEEP; PRP; SUSCEPTIBILITY; PROPAGATION; VARIANTS;

D O I：

10.1007/s11033-008-9312-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prion diseases are fatal neurodegenerative disorders of humans and certain other mammals. Prion protein gene (Prnp) is associated with susceptibility and species barrier to prion diseases. No natural and experimental prion diseases have been documented to date in Arctic fox. In the present study, coding region of Prnp from 135 Arctic foxes were cloned and screened for polymorphisms. Our results indicated that the Arctic fox Prnp open reading frame (ORF) contains 771 nucleotides encoding 257 amino acids. Four single nucleotide polymorphisms (SNPs) (G312C, A337G, C541T, and A723G) were identified. SNPs G312C and A723G produced silent mutations, but SNPs A337G and C541T resulted in a M-V change at codon 113 and R-C at codon 181, respectively. The Arctic fox Prnp amino acid sequence was similar to that of the dog (XM 542906). In short, this study provides preliminary information about genotypes of Prnp in Arctic fox.

引用

页码：1299 / 1303

页数：5

共 28 条

[1] PrP genotype contributes to determining survival times of sheep with natural scrapie [J].

Bossers, A ;

Schreuder, BEC ;

Muileman, IH ;

Belt, PBGM ;

Smits, MA .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :2669-2673

[2] Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP [J].

Bossers, A ;

de Vries, R ;

Smits, MA .

JOURNAL OF VIROLOGY, 2000, 74 (03) :1407-1414

[3] IATROGENIC CREUTZFELDT-JAKOB-DISEASE - AN EXAMPLE OF THE INTERPLAY BETWEEN ANCIENT GENES AND MODERN MEDICINE [J].

BROWN, P ;

CERVENAKOVA, L ;

GOLDFARB, LG ;

MCCOMBIE, WR ;

RUBENSTEIN, R ;

WILL, RG ;

POCCHIARI, M ;

MARTINEZLAGE, JF ;

SCALICI, C ;

MASULLO, C ;

GRAUPERA, G ;

LIGAN, J ;

GAJDUSEK, DC .

NEUROLOGY, 1994, 44 (02) :291-293

[4] DIFFERENT ALLELIC EFFECTS OF THE CODON-136 AND CODON-171 OF THE PRION PROTEIN GENE IN SHEEP WITH NATURAL SCRAPIE [J].

CLOUSCARD, C ;

BEAUDRY, P ;

ELSEN, JM ;

MILAN, D ;

DUSSAUCY, M ;

BOUNNEAU, C ;

SCHELCHER, F ;

CHATELAIN, J ;

LAUNAY, JM ;

LAPLANCHE, JL .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :2097-2101

[5] GENETIC PREDISPOSITION TO IATROGENIC CREUTZFELDT-JAKOB DISEASE [J].

COLLINGE, J ;

PALMER, MS ;

DRYDEN, AJ .

LANCET, 1991, 337 (8755) :1441-1442

[6]

*EUR ALL CTRIES ST, 2008, VAR CREUTZF JAK DIS

[7] Frequencies of PrP gene haplotypes in British sheep flocks and the implications for breeding programmes [J].

Goldmann, W ;

Baylis, M ;

Chihota, C ;

Stevenson, E ;

Hunter, N .

JOURNAL OF APPLIED MICROBIOLOGY, 2005, 98 (06) :1294-1302

[8] The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation [J].

Green, Kristi M. ;

Browning, Shawn R. ;

Seward, Tanya S. ;

Jewell, Jean E. ;

Ross, Dana L. ;

Green, Michael A. ;

Williams, Elizabeth S. ;

Hoover, Edward A. ;

Telling, Glenn C. .

JOURNAL OF GENERAL VIROLOGY, 2008, 89 :598-608

[9]

HADLOW WJ, 1987, CAN J VET RES, V51, P135

[10] SUSCEPTIBILITY OF MINK TO SHEEP SCRAPIE [J].

HANSON, RP ;

ECKROADE, RJ ;

MARSH, RF ;

ZURHEIN, GM ;

KANITZ, CL ;

GUSTAFSON, DP .

SCIENCE, 1971, 172 (3985) :859-+

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