KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study

被引：6
|
作者：
Bassetti, Matteo [1 ,2 ]
Carannante, Novella [3 ]
Pallotto, Carlo [3 ,4 ]
Righi, Elda [1 ,2 ]
Di Caprio, Giovanni [5 ]
Bernardo, Mariano [6 ]
Sodano, Giuseppe [6 ]
Mallardo, Enza [6 ]
Francisci, Daniela [4 ]
Sartor, Assunta [1 ,2 ]
Graziano, Elena [1 ,2 ]
Tascini, Carlo [3 ]
机构：
[1] Univ Udine, Dept Med, Infect Dis Div, Piazzale Santa Maria Misericordia 15, Udine, Italy
[2] Santa Maria Misericordia Univ Hosp, Piazzale Santa Maria Misericordia 15, Udine, Italy
[3] AORN Colli, Cotugno Hosp, Div Infect Dis 1, Via G Quagliariello 51, I-80131 Naples, Italy
[4] Univ Perugia, Dept Med, Infect Dis Sect, Piazzale Gambuli 1, Perugia, Italy
[5] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, Infect Dis Sect, Naples, Italy
[6] AORN Colli, Cotugno Hosp, Microbiol & Virol Unit, Via G Quagliariello 51, Naples, Italy
来源：
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2019年 / 17卷
关键词：
Carbapenemase-producing Klebsiella pneumoniae; KPC; Ceftazidime/avibactam; Ceftazidime; Gut decolonisation; ORAL GENTAMICIN; RESISTANT; DECONTAMINATION; INFECTIONS; COLONIZATION; ERADICATION;
D O I：
10.1016/j.jgar.2018.11.014
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonisation is a major risk factor for developing systemic infection. Ceftazidime/avibactam (CAZ/AVI) may have a role as decolonisation therapy in special situations. Methods: This was a retrospective, observational, multicentre study. The KPC-Kp gut decolonisation rate of CAZ/AVI-based therapy (Group A) was compared with other antimicrobial regimens (Group B) in patients with KPC-Kp infection. Results: Among 12 patients in Group A, 11 (91.7%) achieved gut decolonisation. None of the 24 patients of Group B were decolonised. Conclusion: CAZ/AVI-based therapy could be useful in KPC-Kp gut decolonisation in high-risk patients. (C) 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：109 / 111
页数：3
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