Important Flavonoids and Their Role as a Therapeutic Agent

被引:748
作者
Ullah, Asad [1 ]
Munir, Sidra [1 ]
Badshah, Syed Lal [1 ]
Khan, Noreen [1 ]
Ghani, Lubna [2 ]
Poulson, Benjamin Gabriel [3 ]
Emwas, Abdul-Hamid [4 ]
Jaremko, Mariusz [3 ]
机构
[1] Islamia Coll Univ Peshawar, Dept Chem, Peshawar 25120, Pakistan
[2] Univ Azad Jammu & Kashmir, Muzaffarabad 13230, Dept Chem, Pakistan
[3] King Abdullah Univ Sci & Technol KAUST, Div Biol & Environm Sci & Engn BESE, Thuwal 239556900, Saudi Arabia
[4] King Abdullah Univ Sci & Technol KAUST, Core Labs, Thuwal 239556900, Saudi Arabia
来源
MOLECULES | 2020年 / 25卷 / 22期
关键词
flavonoids; polyphenols; quercetin; antioxidative; neuroprotective; ANTI-ANGIOGENIC ACTIVITY; IN-VITRO; ANTIOXIDANT PROPERTIES; BIOLOGICAL-ACTIVITIES; HUMAN HEALTH; MOLECULAR-MECHANISMS; TRADITIONAL USES; ANTIINFLAMMATORY PROPERTIES; SCUTELLARIA-BAICALENSIS; ANTIBACTERIAL ACTIVITY;
D O I
10.3390/molecules25225243
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.
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页数:39
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