Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer

被引：55

作者：

Wilson, David M. ^{[1
]}

Kurhanewicz, John ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2014年 / 55卷 / 10期

基金：

美国国家卫生研究院;

关键词：

PET/MR imaging; PET/MRI; C-13-magnetic resonance; prostate; prostate cancer; hyperpolarized C-13; metabolism; CARCINOMA-CELLS; LACTATE; RADIOTHERAPY; METABOLISM; EXPRESSION;

D O I：

10.2967/jnumed.114.141705

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using C-13-enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized C-13 MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized C-13 MR spectroscopy, and the development of new platforms for metabolic study.

引用

页码：1567 / 1572

页数：6

共 31 条

[1] Controversies in the Treatment of High-Risk Prostate Cancer-what Is the Optimal Combination of Hormonal Therapy and Radiotherapy: A Review of Literature [J].

Al-Mamgani, Abrahim ;

Lebesque, Joos V. ;

Heemsbergen, Wilma D. ;

Tans, Lisa ;

Kirkels, Wim J. ;

Levendag, Peter C. ;

Incrocci, Luca .

PROSTATE, 2010, 70 (07) :701-709

[2] Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading [J].

Albers, Mark J. ;

Bok, Robert ;

Chen, Albert P. ;

Cunningham, Charles H. ;

Zierhut, Matt L. ;

Zhang, Vickie Yi ;

Kohler, Susan J. ;

Tropp, James ;

Hurd, Ralph E. ;

Yen, Yi-Fen ;

Nelson, Sarah J. ;

Vigneron, Daniel B. ;

Kurhanewicz, John .

CANCER RESEARCH, 2008, 68 (20) :8607-8615

[3] Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR [J].

Ardenkjaer-Larsen, JH ;

Fridlund, B ;

Gram, A ;

Hansson, G ;

Hansson, L ;

Lerche, MH ;

Servin, R ;

Thaning, M ;

Golman, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10158-10163

[4] Challenges in Recognizing Treatment-Related Neuroendocrine Prostate Cancer [J].

Beltran, Himisha ;

Tagawa, Scott T. ;

Park, Kyung ;

MacDonald, Theresa ;

Milowsky, Matthew I. ;

Mosquera, Juan Miguel ;

Rubin, Mark A. ;

Nanus, David M. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (36) :E386-E389

[5] Hyperpolarized [1-13C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a Probe for Imaging Redox Status in Vivo [J].

Bohndiek, Sarah E. ;

Kettunen, Mikko I. ;

Hu, De-en ;

Kennedy, Brett W. C. ;

Boren, Joan ;

Gallagher, Ferdia A. ;

Brindle, Kevin M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (30) :11795-11801

[6] Is Cancer a Metabolic Disease? [J].

Coller, Hilary A. .

AMERICAN JOURNAL OF PATHOLOGY, 2014, 184 (01) :4-17

[7] Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance [J].

Fantin, Valeria R. ;

St-Pierre, Julie ;

Leder, Philip .

CANCER CELL, 2006, 9 (06) :425-434

[8] 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine [J].

Gallagher, Ferdia A. ;

Kettunen, Mikko I. ;

Day, Sam E. ;

Lerche, Mathilde ;

Brindle, Kevin M. .

MAGNETIC RESONANCE IN MEDICINE, 2008, 60 (02) :253-257

[9] Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate [J].

Gallagher, Ferdia A. ;

Kettunen, Mikko I. ;

Day, Sam E. ;

Hu, De-En ;

Ardenkjær-Larsen, Jan Henrik ;

in't Zandt, Rene ;

Jensen, Pernille R. ;

Karlsson, Magnus ;

Golman, Klaes ;

Lerche, Mathilde H. ;

Brindle, Kevin M. .

NATURE, 2008, 453 (7197) :940-U73

[10] c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism [J].

Gao, Ping ;

Tchernyshyov, Irina ;

Chang, Tsung-Cheng ;

Lee, Yun-Sil ;

Kita, Kayoko ;

Ochi, Takafumi ;

Zeller, Karen I. ;

De Marzo, Angelo M. ;

Van Eyk, Jennifer E. ;

Mendell, Joshua T. ;

Dang, Chi V. .

NATURE, 2009, 458 (7239) :762-U100

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