A Metal-Free Route to CF3-Containing Oxindoles by PhI(OAc)2-Mediated Trifluoromethylation of N-Arylacrylamides with TMSCF3

被引：59

作者：

Fu, Weijun ^{[1
]}

Xu, Fengjuan ^{[2
]}

Fu, Yuqin ^{[1
]}

Xu, Chen ^{[1
]}

Li, Shihui ^{[1
]}

Zou, Dapeng ^{[2
]}

机构：

[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Luoyang 471022, Peoples R China

[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Amides; Fluorine; Iodine; Heterocycles; COPPER-CATALYZED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; OXIDATIVE TRIFLUOROMETHYLATION; ACTIVATED ALKENES; BOND FORMATION; SELECTIVE TRIFLUOROMETHYLATION; 2-TRIFLUOROMETHYL QUINOLINES; H FUNCTIONALIZATION; EFFICIENT SYNTHESIS; TERMINAL ALKYNES;

D O I：

10.1002/ejoc.201301512

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient PhI(OAc)(2)-mediated trifluoromethylation reaction of N-arylacrylamides with TMSCF3 under metal-free conditions was developed. This method provides convenient access to a variety of useful CF3-containing oxindoles in moderate to good yields.

引用

页码：709 / 712

页数：4

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