Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vγ9Vδ2 T cells in chronically infected patients undergoing structured treatment interruption

被引：39

作者：

Martini, F ^{[1
]}

Poccia, F ^{[1
]}

Goletti, D ^{[1
]}

Carrara, S ^{[1
]}

Vincenti, D ^{[1
]}

D'Offizi, G ^{[1
]}

Agrati, C ^{[1
]}

Ippolito, G ^{[1
]}

Colizzi, V ^{[1
]}

Pucillo, LP ^{[1
]}

Montesano, C ^{[1
]}

机构：

[1] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Clin Pathol Lab, Int Ctr AIDS & Emerging Infect, I-00149 Rome, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2002年 / 186卷 / 06期

关键词：

D O I：

10.1086/342410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells expressing Vgamma9Vdelta2 display lytic and proliferative responses against human immunodeficiency virus (HIV)-infected cells and release antiviral soluble factors. Chronic HIV-positive patients have deep changes in the composition and function of the circulating gammadelta T cell pool that are restored by highly active antiretroviral therapy (HAART). gammadelta T cells were analyzed during the rapid plasma HIV RNA rebound in HIV-infected patients undergoing structured treatment interruption (STI). A loss in circulating Vgamma9Vdelta2 T cells was observed, indicating that acute HIV replication may influence Vgamma9Vdelta2 homeostasis. These cells were lost among CD45RA(-)CD27(-) Vgamma9Vdelta2 T cell effectors, and a significant unresponsiveness, measured as antigen-driven interferon-gamma production, was observed during STI. After HAART resumption and consequent inhibition of HIV replication, Vgamma9Vdelta2 T cell reactivity was restored both quantitatively and functionally. These observations indicate that Vgamma9Vdelta2 T cells are activated early after active HIV replication but are rapidly lost when viremia is not controlled.

引用

页码：847 / 850

页数：4

共 15 条

[1] Functional inactivation in the whole population of human V gamma 9/V delta 2 T lymphocytes induced by a nonpeptidic antagonist [J].