Gene therapy for age-related macular degeneration

被引：5

作者：

MacLaren, Robert E. ^{[1
,2
,3
]}

机构：

[1] Univ Oxford, Dept Clin Neurosci, Nuffield Lab Ophthalmol, Oxford OX3 9DU, England

[2] Univ Oxford, Hosp Eye, Oxford OX3 9DU, England

[3] Moorfields Eye Hosp NHS Fdn Trust, London, England

来源：

LANCET | 2015年 / 386卷 / 10011期

基金：

英国惠康基金;

关键词：

NONHUMAN-PRIMATES; DELIVERY; RETINA;

D O I：

10.1016/S0140-6736(15)00346-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2369 / 2370

页数：2

共 13 条

[1]

Bainbridge JW, 2002, GENE THER, V9, P320

[2] Causes of vision loss worldwide, 1990-2010: a systematic analysis [J].

Bourne, Rupert R. A. ;

Stevens, Gretchen A. ;

White, Richard A. ;

Smith, Jennifer L. ;

Flaxman, Seth R. ;

Price, Holly ;

Jonas, Jost B. ;

Keeffe, Jill ;

Leasher, Janet ;

Naidoo, Kovin ;

Pesudovs, Konrad ;

Resnikoff, Serge ;

Taylor, Hugh R. .

LANCET GLOBAL HEALTH, 2013, 1 (06) :E339-E349

[3] Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a phase I clinical trial [J].

Campochiaro, PA ;

Nguyen, QD ;

Shah, SM ;

Klein, ML ;

Holz, E ;

Frank, RN ;

Saperstein, DA ;

Gupta, A ;

Stout, JT ;

Macko, J ;

DiBartolomeo, R ;

Wei, LL .

HUMAN GENE THERAPY, 2006, 17 (02) :167-176

[4] Advances in AAV Vector Development for Gene Therapy in the Retina [J].

Day, Timothy P. ;

Byrne, Leah C. ;

Schaffer, David V. ;

Flannery, John G. .

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY, 2014, 801 :687-693

[5] Risk of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials [J].

Grunwald, Juan E. ;

Daniel, Ebenezer ;

Huang, Jiayan ;

Ying, Gui-shuang ;

Maguire, Maureen G. ;

Toth, Cynthia A. ;

Jaffe, Glenn J. ;

Fine, Stuart L. ;

Blodi, Barbara ;

Klein, Michael L. ;

Martin, Alison A. ;

Hagstrom, Stephanie A. ;

Martin, Daniel F. .

OPHTHALMOLOGY, 2014, 121 (01) :150-161

[6] Implantable MicroPump for Drug Delivery in Patients with Diabetic Macular Edema [J].

Humayun, Mark ;

Santos, Arturo ;

Carlos Altamirano, Juan ;

Ribeiro, Ramiro ;

Gonzalez, Roberto ;

de la Rosa, Alejandro ;

Shih, Jason ;

Pang, Changling ;

Jiang, Fukang ;

Calvillo, Philip ;

Huculak, John ;

Zimmerman, Jenna ;

Caffey, Sean .

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2014, 3 (06)

[7] Age-related macular degeneration and the complement system [J].

Khandhadia, S. ;

Cipriani, V. ;

Yates, J. R. W. ;

Lotery, A. J. .

IMMUNOBIOLOGY, 2012, 217 (02) :127-146

[8] Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates [J].

Kotterman, M. A. ;

Yin, L. ;

Strazzeri, J. M. ;

Flannery, J. G. ;

Merigan, W. H. ;

Schaffer, D. V. .

GENE THERAPY, 2015, 22 (02) :116-126

[9] Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates [J].

Lai, C-M ;

Estcourt, M. J. ;

Himbeck, R. P. ;

Lee, S-Y ;

Yeo, I. Yew-San ;

Luu, C. ;

Loh, B. K. ;

Lee, M. W. ;

Barathi, A. ;

Villano, J. ;

Ang, C-L ;

van der Most, R. G. ;

Constable, I. J. ;

Dismuke, D. ;

Samulski, R. J. ;

Degli-Esposti, M. A. ;

Rakoczy, E. P. .

GENE THERAPY, 2012, 19 (10) :999-1009

[10] Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain [J].

Paterna, JC ;

Moccetti, T ;

Mura, A ;

Feldon, J ;

Büeler, H .

GENE THERAPY, 2000, 7 (15) :1304-1311

← 1 2 →