Amygdalar opioids modulate hypothalamic melanocortin-induced anorexia

被引:29
作者
Beckman, Tiffany R. [1 ]
Shi, Qiuying [2 ]
Levine, Allen S. [2 ,3 ]
Billington, Charles J. [1 ,2 ]
机构
[1] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Minnesota Obes Ctr, St Paul, MN 55108 USA
[3] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA
关键词
Opioids; Melanocortins; Food intake; Reward; Brain; Limbic; Amygdala; Hypothalamus; MELANOCYTE-STIMULATING HORMONE; FOS-LIKE IMMUNOREACTIVITY; VENTRAL TEGMENTAL AREA; FOOD-INTAKE; PARAVENTRICULAR NUCLEUS; NEUROPEPTIDE-Y; NEUROANATOMICAL PATTERNS; SOLITARY TRACT; ALPHA-MSH; RECEPTOR;
D O I
10.1016/j.physbeh.2008.12.007
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
We wanted to assess the possibility that opioid activity in the central amygdala (CeA) could modulate the feeding inhibition of melanocortin stimulation of the paraventricular hypothalamus (PVN). The melanocortin system is important in both the acute regulation of satiety and feeding behavior and in the integration of long-term appetite signals. Melanotan II (MTII) is a synthetic MC3R and MC4R agonist which reduces food intake when given intracerebroventricularly (ICV) and into the PVN. Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO), a mu-opioid receptor agonist, increases food intake, while opioid antagonists, like naltrexone (NTX), inhibit food intake after injection into many brain sites involved in appetite regulation, including the CeA. In food-deprived male Sprague-Dawley rats, co-injected intra-PVN MTII partially blocked the orexigenic effect of co-injected intra-CeA DAMGO. Intra-CeA NTX co-injected with intra-PVN MTII reduced food intake significantly more than either alone. NTX administered intra-CeA reduced c-Fos-immunoreactivity (IR) in nucleus accumbens neurons significantly compared to the intra-PVN MTII treated animals, animals co-injected intra-PVN with MTII and intra-CeA with NTX animals. and control animals. Intra-PVN MTII induced c-Fos-IR in significantly more PVN neurons than observed in control animals. Intra-CeA NTX co-injected with intra-PVN MTII induced c-Fos-IR significantly in PVN neurons relative to control and intra-CeA NTX animals. Such data support the significance of opioid action within the CeA as a modulator of the feeding regulation action of melanocortins within the PVN, occurring within the context of a larger appetitive network. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:568 / 573
页数:6
相关论文
共 59 条
[31]   ENDORPHINERGIC AND ALPHA-NORADRENERGIC SYSTEMS IN THE PARAVENTRICULAR NUCLEUS - EFFECTS ON EATING BEHAVIOR [J].
LEIBOWITZ, SF ;
HOR, L .
PEPTIDES, 1982, 3 (03) :421-428
[32]   The animal model in food intake regulation: Examples from the opioid literature [J].
Levine, Allen S. .
PHYSIOLOGY & BEHAVIOR, 2006, 89 (01) :92-96
[33]   Opioids as agents of reward-related feeding: a consideration of the evidence [J].
Levine, AS ;
Billington, CJ .
PHYSIOLOGY & BEHAVIOR, 2004, 82 (01) :57-61
[34]   Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior [J].
Levine, AS ;
Olszewski, PK ;
Mullett, MA ;
Pomonis, JD ;
Grace, MK ;
Kotz, CM ;
Billington, CJ .
BRAIN RESEARCH, 2004, 1015 (1-2) :9-14
[35]  
LEVINE AS, 1996, PEPTIDES REGULATION
[36]  
LEVINE AS, 1994, AM J PHYSIOL-REG I, pR248
[37]   Alterations in food intake by oploid and dopamine signaling pathways between the ventral tegmental area and the shell of the nucleus accumbens [J].
MacDonald, AF ;
Billington, CJ ;
Levine, AS .
BRAIN RESEARCH, 2004, 1018 (01) :78-85
[38]   Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat [J].
MacDonald, AF ;
Billington, CJ ;
Levine, AS .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 285 (05) :R999-R1004
[39]   Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression [J].
McMinn, JE ;
Wilkinson, CW ;
Havel, PJ ;
Woods, SC ;
Schwartz, MW .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (02) :R695-R703
[40]   LOCALIZATION OF THE MELANOCORTIN-4 RECEPTOR (MC4-R) IN NEUROENDOCRINE AND AUTONOMIC CONTROL-CIRCUITS IN THE BRAIN [J].
MOUNTJOY, KG ;
MORTRUD, MT ;
LOW, MJ ;
SIMERLY, RB ;
CONE, RD .
MOLECULAR ENDOCRINOLOGY, 1994, 8 (10) :1298-1308