Efficient enantioselective synthesis of sertraline, a potent antidepressant, via a novel intramolecular nucleophilic addition to imine

被引：44

作者：

Chen, CY ^{[1
]}

Reamer, RA ^{[1
]}

机构：

[1] Merck Res Labs, Proc Res Dept, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1021/ol990608g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An efficient enantioselective synthesis of sertraline, an antidepressant, utilizing anionic imine ring closure is described.

引用

页码：293 / 294

页数：2

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