Quantitative trait locus detection using combined linkage/disequilibrium analysis

被引：0

作者：

Almasy, L ^{[1
]}

Williams, JT ^{[1
]}

Dyer, TD ^{[1
]}

Blangero, J ^{[1
]}

机构：

[1] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA

来源：

GENETIC EPIDEMIOLOGY | 1999年 / 17卷

关键词：

association methods; linkage methods; quantitative trait; statistical genetics;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification. (C) 1999 Wiley-Liss, Inc.

引用

页码：S31 / S36

页数：6

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